Purkinje cell long-term depression is prevented by T-588, a neuroprotective compound that reduces cytosolic calcium release from intracellular stores.

Kimura T; Sugimori M; Llinas RR

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Purkinje cell long-term depression is prevented by T-588, a neuroprotective compound that reduces cytosolic calcium release from intracellular stores.

机译：浦肯野细胞长期抑郁可以通过T-588来预防，T-588是一种神经保护性化合物，可减少细胞内存储物中钙的释放。

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Long-term depression (LTD) of the parallel-fiber (PF) Purkinje synapse induced by four different experimental paradigms could be prevented in rat cerebellar slices by T-588, a neuroprotective compound. The paradigms consisted of pairing PF activation with climbing-fiber activation, direct depolarization, glutamic iontophoretic depolarization, or caffeine. In all cases, LTD was determined by patch-clamp recording of PF excitatory postsynaptic currents at the Purkinje cell somata. T-588 at 1 muM prevented the triggering of LTD reversibly and did not generate LTD on its own. Two-photon calcium-sensitive dye imaging demonstrated that T-588 reduces intracellular calcium concentration ([Ca(2+)](i)) increase by blocking calcium release from intracellular stores. Because [Ca(2+)](i) increase has been widely shown to trigger LTD and glutamate excitotoxicity, we propose that LTD may act as a neuroprotective mechanism. As such, LTD would serve to decrease glutamatergic-receptor sensitivity to limit deleterious [Ca(2+)](i) increase rather than to act as a mechanism for cerebellar learning.

机译：可以通过神经保护性化合物T-588预防大鼠小脑切片中四种不同实验范式引起的平行纤维（PF）浦肯野突触的长期压抑（LTD）。范例包括将PF激活与攀岩纤维激活，直接去极化，谷氨酸离子电渗去极化或咖啡因配对。在所有情况下，LTD均通过膜片钳记录浦肯野细胞体细胞的PF兴奋性突触后电流来确定。 1μM的T-588可逆地阻止LTD的触发，并且不能自行生成LTD。两光子钙敏感染料成像表明，T-588通过阻止钙从细胞内存储中释放而降低了细胞内钙浓度（[Ca（2 +）]（i）的增加。因为[Ca（2 +）]（i）的增加已被广泛显示触发LTD和谷氨酸兴奋性中毒，所以我们建议LTD可以作为神经保护机制。因此，LTD将有助于降低谷氨酸能受体的敏感性，以限制有害的[Ca（2 +）]（i）增加，而不是充当小脑学习的机制。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2005年第47期|P.17160-17165|共6页
作者
Kimura T; Sugimori M; Llinas RR;
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作者单位

Toyama Chemical Company, 2-4-1 Shimookui, Toyama 930-8508, Japan.;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
T 588; Calcium; Intracellular; Cancer patients and suicide and depression; 钙;

机译：T 588;钙;细胞内;癌症患者与自杀和抑郁症;钙;

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1. Cytosolic calmodulin is increased in SK-N-SH human neuroblastoma cells due to release of calcium from intracellular stores. [J] . McGinnis KM, Shariat-Madar Z, Gnegy ME Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 1998,第1期

机译：由于钙从细胞内储库中释放，胞质钙调蛋白在SK-N-SH人成神经细胞瘤细胞中增加。
2. Cannabinoids produce neuroprotection by reducing intracellular calcium release from ryanodine-sensitive stores. [J] . Zhuang SY, Bridges D, Grigorenko E, Neuropharmacology . 2005,第8期

机译：大麻素可通过减少细胞内钙盐从敏感碱的释放而产生神经保护作用。
3. Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores. [J] . J B Imboden, J D Stobo The Journal of Experomental Medicine . 1985,第3期

机译：T细胞抗原受体的跨膜信号传导。 T3-抗原受体复合物的扰动产生肌醇磷酸酯，并从细胞内贮存物中释放钙离子。
4. Role of cytosolic calcium diffusion in cardiac purkinje cells [C] . Bijay Limbu, Kushal Shah, Makarand Deo Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2016

机译：胞质钙扩散在心脏浦肯野细胞中的作用
5. Effects of endogenous amphiphilic compounds, intracellular calcium, and intracellularpH on the gap junctional coupling between myocyte: Possible role in myocardial ischemia. [D] . Xie, Zijian. 1990

机译：内源性两亲化合物，细胞内钙和细胞内pH对心肌细胞之间间隙连接偶联的影响：在心肌缺血中的可能作用。
6. Purkinje cell long-term depression is prevented by T-588 a neuroprotective compound that reduces cytosolic calcium release from intracellular stores [O] . Tatsuo Kimura, Mutsuyuki Sugimori, Rodolfo R. Llinás 2005

机译：T-588可预防浦肯野细胞长期抑郁T-588是一种神经保护性化合物可减少细胞内储存物中胞质钙的释放
7. Purkinje cell long-term depression is prevented by T-588, a neuroprotective compound that reduces cytosolic calcium release from intracellular stores [O] . Kimura, Tatsuo, Sugimori, Mutsuyuki, Llinás, Rodolfo R. 2005

机译：T-588可预防浦肯野细胞长期抑郁，T-588是一种神经保护性化合物，可减少细胞内储存物中胞质钙的释放

Purkinje cell long-term depression is prevented by T-588, a neuroprotective compound that reduces cytosolic calcium release from intracellular stores.

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