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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Human cancers overexpress genes that are specific to a variety of normal human tissues.
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Human cancers overexpress genes that are specific to a variety of normal human tissues.

机译：人类癌症过表达特定于各种正常人类组织的基因。

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摘要

We have analyzed gene expression data from three different kinds of samples: normal human tissues, human cancer cell lines, and leukemic cells from lymphoid and myeloid leukemia pediatric patients. We have searched for genes that are overexpressed in human cancer and also show specific patterns of tissue-dependent expression in normal tissues. Using the expression data of the normal tissues, we identified 4,346 genes with a high variability of expression and clustered these genes according to their relative expression level. Of 91 stable clusters obtained, 24 clusters included genes preferentially expressed either only in hematopoietic tissues or in hematopoietic and one to two other tissues; 28 clusters included genes preferentially expressed in various nonhematopoietic tissues such as neuronal, testis, liver, kidney, muscle, lung, pancreas, and placenta. Analysis of the expression levels of these two groups of genes in the human cancer cell lines and leukemias identified genes that were highly expressed in cancer cells but not in their normal counterparts and, thus, were overexpressed in the cancers. The different cancer cell lines and leukemias varied in the number and identity of these overexpressed genes. The results indicate that many genes that are overexpressed in human cancer cells are specific to a variety of normal tissues, including normal tissues other than those from which the cancer originated. It is suggested that this general property of cancer cells plays a major role in determining the behavior of the cancers, including their metastatic potential.
机译：我们分析了三种不同样品的基因表达数据：正常人组织，人癌细胞系以及来自淋巴和髓样白血病小儿患者的白血病细胞。我们已经搜索了在人类癌症中过表达的基因，并且还显示了正常组织中依赖于组织表达的特定模式。利用正常组织的表达数据，我们鉴定了4,346个表达变异性高的基因，并根据它们的相对表达水平将它们聚类。在获得的91个稳定簇中，有24个簇包括仅在造血组织中或在造血组织中以及在另外一到两个其他组织中优先表达的基因。 28个簇包括优先在各种非造血组织（例如神经元，睾丸，肝，肾，肌肉，肺，胰腺和胎盘）中表达的基因。通过对这两组基因在人类癌细胞系和白血病中的表达水平进行分析，可以确定在癌细胞中高表达的基因，但在正常人中却没有，因此在癌症中过表达。这些过量表达的基因的数量和特征不同，癌细胞系和白血病也不同。结果表明，在人类癌细胞中过表达的许多基因对多种正常组织具有特异性，包括不同于癌症起源的那些正常组织。建议癌细胞的这种一般特性在确定癌症的行为（包括其转移潜能）中起主要作用。

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