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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The 4-coumarate:CoA ligase gene family in Arabidopsis thaliana comprises one rare, sinapate-activating and three commonly occurring isoenzymes
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The 4-coumarate:CoA ligase gene family in Arabidopsis thaliana comprises one rare, sinapate-activating and three commonly occurring isoenzymes

机译：拟南芥中的4-香豆酸酯：CoA连接酶基因家族包含一种稀有的，芥子酸酯激活型和三种常见的同工酶

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摘要

4-Coumarate:CoA ligase (4CL; EC 6.2.1.12) has a pivotal role in the biosynthesis of plant secondary compounds at the divergence point from general phenylpropanoid metabolism to several major branch pathways. In Arabidopsis thaliana, we have identified a previously undetected, fourth and final member of the At4CL gene family. The encoded enzyme, At4CL4, exhibits the rare property of efficiently activating sinapate, besides the usual 4CL substrates (4-coumarate, caffeate, and ferulate), indicating a distinct metabolic function. Phylogenetic analysis suggests an early evolutionary and functional divergence of three of the four gene family members, At4CL2-4, whereas At4CL1 appears to have originated much later by duplication of its structurally and functionally closest relative, At4CL2. Various characteristics shared by all known plant 4CL genes, as well as by the encoded proteins, define and delimit the At4CL gene family and distinguish it from the closely related family of "At4CL-like" genes.
机译：4-香豆酸酯：CoA连接酶（4CL； EC 6.2.1.12）在植物次生化合物的生物合成中具有重要作用，其分支点从一般的苯丙烷代谢到一些主要的分支途径。在拟南芥中，我们已经鉴定出At4CL基因家族的一个先前未被发现的第四和最后一个成员。除常见的4CL底物（4-香豆酸盐，咖啡酸盐和阿魏酸盐）外，编码的酶At4CL4还具有罕见的有效活化芥子酸酯的特性，表明其独特的代谢功能。系统发育分析表明，四个基因家族成员中的三个At4CL2-4具有较早的进化和功能差异，而At4CL1似乎是由于其结构和功能上最接近的亲戚At4CL2的复制而产生的。所有已知植物4CL基因以及编码的蛋白质共有的各种特征定义并界定了At4CL基因家族，并将其与“ At4CL样”基因的密切相关家族区别开来。

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