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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Ceramidase expression facilitates membrane turnover and endocytosis of rhodopsin in photoreceptors
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Ceramidase expression facilitates membrane turnover and endocytosis of rhodopsin in photoreceptors

机译：神经酰胺酶的表达促进光感受器中视紫红质的膜更新和内吞作用

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摘要

Transgenic expression of ceramidase suppresses retinal degeneration in Drosophila arrestin and phospholipase C mutants. Here, we show that expression of ceramidase facilitates the dissolution of incompletely formed and inappropriately located elements of rhabdomeric membranes in ninaE~(/17) mutants lacking the G protein receptor Rh1 in R1-R6 photoreceptor cells. Ceramidase expression facilitates the endocytic turnover of Rh1. Although ceramidase expression aids the removal of internalized rhodopsin, it does not affect the turnover of Rh1 in photoreceptors maintained in dark, where Rh1 is not activated and thus has a slower turnover and a long half-life. Therefore, the phenotypic consequence of ceramidase expression in photoreceptors is caused by facilitation of endocytosis. This study provides mechanistic insight into the sphin-golipid biosynthetic pathway-mediated modulation of endocytosis and suppression of retinal degeneration.
机译：ceramidase的转基因表达抑制果蝇抑制蛋白和磷脂酶C突变体中的视网膜变性。在这里，我们显示了神经酰胺酶的表达促进了R1-R6感光细胞中缺少G蛋白受体Rh1的ninaE〜（/ 17）突变体中横纹膜的不完全形成和定位不当的元素的溶解。神经酰胺酶表达促进Rh1的内吞周转。尽管神经酰胺酶表达有助于去除内在的视紫红质，但它并不影响在黑暗中保持Rh1未被激活的感光器中Rh1的转换，因此转换较慢且半衰期较长。因此，感光细胞中神经酰胺酶表达的表型结果是由内吞作用的促进引起的。这项研究提供了机制，以了解鞘磷脂的生物合成途径介导的内吞作用的调节和视网膜变性的抑制。

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