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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Coordinate enhancers share common organizational features in the Drosophila genome
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Coordinate enhancers share common organizational features in the Drosophila genome

机译：协调增强子在果蝇基因组中共有共同的组织特征

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摘要

The evolution of animal diversity depends on changes in the regulation of a relatively fixed set of protein-coding genes. To understand how these changes might arise, we examined the organization of shared sequence motifs in four coordinately regulated neurogenic enhancers that direct similar patterns of gene expression in the early Drosophila embryo. All four enhancers possess similar arrangements of a subset of putative regulatory elements. These shared features were used to identify a neurogenic enhancer in the distantly related Anopheles genome. We suggest that the constrained organization of metazoan enhancers may be essential for their ability to produce precise patterns of gene expression during development. Organized binding sites should facilitate the identification of regulatory codes that link primary DNA sequence information with predicted patterns of gene activity. [References: 19]
机译：动物多样性的演变取决于相对固定的一组蛋白质编码基因调控的变化。为了解这些变化可能如何发生，我们研究了四个协调调控的神经原性增强子中共享序列基序的组织，这些增强子指导果蝇早期胚胎中基因表达的相似模式。所有四个增强子都具有假定的调节元件子集的相似排列。这些共有的特征被用于识别远缘的按蚊基因组中的神经源性增强子。我们建议，后生动物增强子的受约束的组织可能对他们在发育过程中产生精确的基因表达模式的能力至关重要。有组织的结合位点应有助于鉴定将基本DNA序列信息与基因活性的预测模式相关联的调节代码。 [参考：19]

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