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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Peroxisome proliferator-activated receptor γ is required in mature white and brown adipocytes for their survival in the mouse
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Peroxisome proliferator-activated receptor γ is required in mature white and brown adipocytes for their survival in the mouse

机译：过氧化物酶体增殖物激活受体γ是成熟的白色和棕色脂肪细胞在小鼠中生存所必需的

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摘要

The peroxisome proliferator-activated receptor γ (PPARγ) mediates the activity of the insulin-sensitizing thiazolidinediones and plays an important role in adipocyte differentiation and fat accretion. The analysis of PPARγ functions in mature adipocytes is precluded by lethality of PPARγ~(-/-) fetuses and tetraploid-rescued pups. Therefore we have selectively ablated PPARγ in adipocytes of adult mice by using the tamoxifen-dependent Cre-ER~(T2) recombination system. We show that mature PPARγ-null white and brown adipocytes die within a few days and are replaced by newly formed PPARγ-positive adipocytes, demonstrating that PPARγ is essential for the in vivo survival of mature adipocytes, in addition to its well established requirement for their differentiation. Our data suggest that potent PPARγ antagonists could be used to acutely reduce obesity.
机译：过氧化物酶体增殖物激活受体γ（PPARγ）介导胰岛素敏感性噻唑烷二酮的活性，并在脂肪细胞分化和脂肪积聚中起重要作用。 PPARγ〜（-/-）胎儿和四倍体拯救的幼仔的致死性排除了对成熟脂肪细胞中PPARγ功能的分析。因此，我们使用他莫昔芬依赖性的Cre-ER〜（T2）重组系统选择性去除了成年小鼠脂肪细胞中的PPARγ。我们显示，成熟的PPARγ无效的白色和棕色脂肪细胞会在几天内死亡，并被新形成的PPARγ阳性脂肪细胞取代，这表明PPARγ对成熟脂肪细胞的体内存活至关重要，此外，其对脂肪细胞的成熟要求也很高。差异化。我们的数据表明有效的PPARγ拮抗剂可用于急性减轻肥胖。

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