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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study.
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Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study.

机译：乙酰胆碱酯酶/对氧磷酶的基因型和表达可预测健康，危险因素，运动训练和遗传学研究中的焦虑评分。

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摘要

Anxiety involves complex, incompletely understood interactions of genomic, environmental, and experience-derived factors, and is currently being measured by psychological criteria. Here, we report previously nonperceived interrelationships between expression variations and nucleotide polymorphisms of the chromosome 7q21-22 acetylcholinesterase-paraoxonase 1 (ACHE-PON1) locus with the trait- and state-anxiety measures of 461 healthy subjects from the Health, Risk Factors, Exercise Training, and Genetics Family Study. The AChE protein controls the termination of the stress-enhanced acetylcholine signaling, whereas the PON protein displays peroxidase-like activity, thus protecting blood proteins from oxidative stress damages. Serum AChE and PON enzyme activities were both found to be affected by demographic parameters, and showed inverse, reciprocal associations with anxiety measures. Moreover, the transient scores of state anxiety and the susceptibility score of trait anxiety both appeared to be linked to enzyme activities. This finding supported the notion of corresponding gene expression relationships. Parallel polymorphisms in the ACHE and PON1 genes displayed apparent associations with both trait- and state-anxiety scores. Our findings indicate that a significant source of anxiety feelings involves inherited and acquired parameters of acetylcholine regulation that can be readily quantified, which can help explaining part of the human variance for state and trait anxiety.
机译：焦虑症涉及基因组，环境和经验因素之间复杂的，不完全了解的相互作用，目前正在通过心理标准进行评估。在这里，我们报道了来自健康，风险因素，运动的461名健康受试者的性状和状态焦虑量度，先前报道的染色体7q21-22乙酰胆碱酯酶-对氧磷酶1（ACHE-PON1）基因座的表达变异与核苷酸多态性之间存在不可感知的相互关系。培训和遗传学家庭研究。 AChE蛋白控制着增强应激的乙酰胆碱信号的终止，而PON蛋白则表现出过氧化物酶样活性，从而保护了血液蛋白免受氧化应激损伤。发现血清AChE和PON酶的活性均受人口统计学参数的影响，并显示出与焦虑测量值成反比，倒数关联。而且，状态焦虑的瞬时评分和性格焦虑的易感性评分似乎都与酶活性有关。这一发现支持了相应基因表达关系的概念。 ACHE和PON1基因的平行多态性表现出与特质和状态焦虑评分的明显关联。我们的发现表明，焦虑感的重要来源涉及乙酰胆碱调节的遗传参数和后天获得的参数，这些参数很容易量化，这可以帮助解释人类对于状态和特质焦虑的部分变异。

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