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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Myosin V processivity: multiple kinetic pathways for head-to-head coordination.
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Myosin V processivity: multiple kinetic pathways for head-to-head coordination.

机译:肌球蛋白V合成能力:多种动力学途径可实现头对头协调。

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摘要

Myosin V, a double-headed molecular motor, transports organelles within cells by walking processively along actin, a process that requires coordination between the heads. To understand the mechanism underlying this coordination, processive runs of single myosin V molecules were perturbed by varying nucleotide content. Contrary to current views, our results show that the two heads of a myosin V molecule communicate, not through any one mechanism but through an elaborate system of cooperative mechanisms involving multiple kinetic pathways. These mechanisms introduce redundancy and safeguards that ensure robust processivity under differing physiologic demands.
机译:肌球蛋白V(Myosin V)是一种双头分子电动机,通过沿着肌动蛋白的过程进行步移,从而在细胞内运输细胞器,这一过程需要头部之间的协调。为了了解这种协调的机制,单个肌球蛋白V分子的连续运行受到核苷酸含量变化的干扰。与当前观点相反,我们的结果表明,肌球蛋白V分子的两个头部之间不是通过任何一种机制而是通过复杂的涉及多种动力学途径的协同机制系统进行通讯。这些机制引入了冗余和保护措施,以确保在不同的生理要求下具有强大的持续性。

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