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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Identification of the antivasopermeability effect of pigment epithelium-derived factor and its active site
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Identification of the antivasopermeability effect of pigment epithelium-derived factor and its active site

机译：色素上皮衍生因子及其活性部位的抗血管渗透作用的鉴定

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摘要

Vascular permeability plays a key role in a wide array of life-threatening and sight-threatening diseases. Vascular endothelial growth factor can increase vascular permeability. Using a model system for nonproliferative diabetic retinopathy, we found that pigment epithelium-derived factor (PEDF) effectively abated vascular endothelial growth factor-induced vascular permeability. A 44-amino acid region of PEDF was sufficient to confer the antivasopermeability activity. Additionally, we identified four amino acids (glutamate-101, isoleucine-103, leucine-112, and serine-115) critical for this activity. PEDF, or a derivative, could potentially abate or restore vision loss from diabetic macular edema. Furthermore, PEDF may represent a superior therapeutic approach to sepsis-associated hypotension, nephrotic syndrome, and other sight-threatening and life-threatening diseases resulting from excessive vascular permeability.
机译：血管通透性在许多威胁生命和视力的疾病中起关键作用。血管内皮生长因子可增加血管通透性。使用非增生性糖尿病视网膜病变模型系统，我们发现色素上皮衍生因子（PEDF）可有效减轻血管内皮生长因子诱导的血管通透性。 PEDF的44个氨基酸区域足以赋予抗血管通透性。此外，我们确定了对此活动至关重要的四个氨基酸（谷氨酸101，异亮氨酸103，亮氨酸112和丝氨酸115）。 PEDF或其衍生物可能会减轻或恢复糖尿病性黄斑水肿引起的视力丧失。此外，PEDF可能代表败血症相关性低血压，肾病综合征和其他因血管通透性过高而导致视力和生命受到威胁的疾病的治疗方法。

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