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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Pseudomonas aeruginosa regulates flagellin expression as part of a global response to airway fluid from cystic fibrosis patients
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Pseudomonas aeruginosa regulates flagellin expression as part of a global response to airway fluid from cystic fibrosis patients

机译：铜绿假单胞菌调节鞭毛蛋白表达，作为对囊性纤维化患者气道液整体反应的一部分

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摘要

Cystic fibrosis (CF) patients are highly susceptible to chronic lung infections by the environmental bacterium Pseudomonas aeruginosa. The overproduction and accumulation of dehydrated viscous respiratory mucus and excessive inflammation represents a defining feature of CF and constitutes the major environment encountered by A aeruginosa during chronic infections. We applied whole-genome microarray technology to investigate the ability of P. aeruginosa to respond to signals found in muco-purulent airway liquids collected from chronically infected CIF patients. Particularly notable was the activation of the Rhl-dependent quorum-sensing (QS) network and repression of MC, which encodes flagellin. Activation of the Rhl branch of the QS network supports the observation that QS molecules are produced in the chronically infected CF lung. The shut-off of flagellin synthesis in response to CIF airway liquids was rapid and independent of QS and the known regulatory networks controlling the hierarchical expression of flagellar genes. As flagellin is highly immunogenic and subject to detection by host pattern recognition receptors, its repression may represent an adaptive response that allows A aeruginosa to avoid detection by host defense mechanisms and phagocytosis during the chronic phase of CIF lung infections.
机译：囊性纤维化（CF）患者高度易受环境细菌铜绿假单胞菌（Pseudomonas aeruginosa）慢性肺部感染的影响。脱水粘性呼吸道粘液的过度产生和积累以及过度炎症代表了CF的主要特征，并构成了铜绿假单胞菌在慢性感染过程中遇到的主要环境。我们应用全基因组微阵列技术研究铜绿假单胞菌对从慢性感染CIF患者收集的粘液化脓性气道液中发现的信号作出反应的能力。特别值得注意的是依赖Rhl的群体感应（QS）网络的激活和编码鞭毛蛋白的MC的抑制。 QS网络的Rhl分支的激活支持观察到QS分子在慢性感染的CF肺中产生。响应CIF气道液体，鞭毛蛋白合成的关闭是迅速的，并且与QS和控制鞭毛基因分层表达的已知调节网络无关。由于鞭毛蛋白具有高度的免疫原性，并且可以通过宿主模式识别受体进行检测，因此其抑制作用可能代表一种适应性反应，使铜绿假单胞菌可以避免在慢性CIF肺部感染期间通过宿主防御机制和吞噬作用进行检测。

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