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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins.
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Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins.

机译：第1-4位：蛋白磷酸酶1和肌动蛋白调节蛋白家族。

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摘要

Protein phosphatase 1 (PP1) is a multifunctional enzyme with diverse roles in the nervous system, including regulation of synaptic activity and dendritic morphology. PP1 activity is controlled via association with a family of regulatory subunits that govern subcellular localization and substrate specificity. A previously undescribed class of PP1-binding proteins was detected by interaction cloning. Family members were also found to bind to cytoplasmic actin via Arg, Pro, Glu, and Leu repeat-containing sequences. The prototypical member of this family, phosphatase and actin regulator (phactr) 1 was a potent modulator of PP1 activity in vitro. Phactr-1 protein is selectively expressed in brain, where high levels were found in cortex, hippocampus, and striatum, with enrichment of the protein at synapses. Additional family members displayed highly distinct mRNA transcript expression patterns within rat brain. The current findings present a mechanism by which PP1 may be directed toward neuronal substrates associated with the actin cytoskeleton.
机译：磷酸酶1（PP1）是一种多功能酶，在神经系统中具有多种作用，包括调节突触活性和树突形态。 PP1活性通过与控制亚细胞定位和底物特异性的调控亚基家族的结合来控制。通过相互作用克隆检测到先前未描述的一类PP1结合蛋白。还发现家族成员通过含Arg，Pro，Glu和Leu重复序列与细胞质肌动蛋白结合。该家族的原型成员磷酸酶和肌动蛋白调节剂（phactr）1是体外PP1活性的有效调节剂。 Phactr-1蛋白在大脑中有选择性地表达，在大脑皮层，海马和纹状体中高水平表达，并且突触中该蛋白富集。其他家族成员在大鼠大脑中显示出高度不同的mRNA转录表达模式。当前的发现提出了一种机制，通过该机制PP1可以被导向与肌动蛋白细胞骨架相关的神经元底物。

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