...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling.
【24h】

Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling.

机译：阴性选择半成熟的CD4（+）8（-）HSA +胸腺细胞需要仅BH3蛋白Bim，但与死亡受体信号无关。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

T cell receptor/CD3 ligation induces apoptosis in semimature CD4(+)8(-)HSA+ thymocytes, and this helps establish immunological tolerance and constitutes one of the safeguards against autoimmune disease. We analyzed several knockout and transgenic mouse lines and found that T cell receptor/CD3-ligation-induced killing of semimature thymocytes occurred independently of Fas and "death receptor" signaling in general but required the proapoptotic BH3-only protein Bim and could be inhibited by Bcl-2. Loss of Apaf-1 or caspase-9, which act downstream of the Bcl-2 family protein family, provided only minor protection, indicating that the apoptosome initiator of this death program. These results reveal the mechanisms of apoptosis in negative selection of semimature thymocytes and have implications for immunological tolerance and autoimmunity.
机译：T细胞受体/ CD3的连接在半成熟的CD4（+）8（-）HSA +胸腺细胞中诱导凋亡，这有助于建立免疫耐受性，并构成针对自身免疫疾病的保障措施之一。我们分析了几种基因敲除和转基因小鼠品系，发现T细胞受体/ CD3连接诱导的对半胸腺细胞的杀伤通常独立于Fas和“死亡受体”信号传导而发生，但需要促凋亡的仅BH3蛋白Bim并可以被抑制Bcl-2。在Bcl-2家族蛋白家族下游起作用的Apaf-1或caspase-9的丧失仅提供了较小的保护，表明该死亡程序的凋亡小分子启动子。这些结果揭示了半成熟胸腺细胞阴性选择中的凋亡机制，并且对免疫耐受和自身免疫具有影响。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号