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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >A balance between the diap1 death inhibitor and reaper and hid death inducers controls steroid-triggered cell death in Drosophila.
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A balance between the diap1 death inhibitor and reaper and hid death inducers controls steroid-triggered cell death in Drosophila.

机译：diap1死亡抑制剂与收割者和hid死亡诱导剂之间的平衡控制了果蝇中类固醇触发的细胞死亡。

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摘要

The steroid hormone ecdysone directs the massive destruction of obsolete larval tissues during Drosophila metamorphosis, providing a model system for defining the molecular mechanisms of steroid-regulated programmed cell death. Although earlier studies have identified an ecdysone triggered genetic cascade that immediately precedes larval tissue cell death, no death regulatory genes have been functionally linked to this death response. We show here that ecdysone-induced expression of the death activator genes reaper (rpr) and head involution defective (hid) is required for destruction of the larval midgut and salivary glands during metamorphosis, with hid playing a primary role in the salivary glands and rpr and hid acting in a redundant manner in the midguts. We also identify the Drosophila inhibitor of apoptosis 1 as a survival factor in the larval cell death pathway, delaying death until its inhibitory effect is overcome by rpr and hid. This study reveals functional interactions between rpr and hid in Drosophila cell death responses and provides evidence that the precise timing of larval tissue cell death during metamorphosis is achieved through a steroid-triggered shift in the balance between the Drosophila inhibitor of apoptosis 1 and the rpr and hid death activators.
机译：类固醇激素蜕皮激素可指导果蝇变态期间陈旧幼虫组织的大规模破坏，为定义类固醇调节程序性细胞死亡的分子机制提供了模型系统。尽管较早的研究已经确定了蜕皮激素触发的遗传级联反应立即发生在幼虫组织细胞死亡之前，但尚无死亡调控基因在功能上与这种死亡反应相关。我们在这里显示蜕皮激素诱导的死亡激活基因收割者（rpr）和头部向内缺陷（hid）的表达是蜕变期间幼虫中肠和唾液腺的破坏所必需的，hid在唾液腺和rpr中起主要作用并以多余的方式隐藏在中肠。我们还确定了果蝇凋亡抑制剂1作为幼虫细胞死亡途径中的生存因子，延迟死亡直至rpr和hid克服了其抑制作用。这项研究揭示了果蝇细胞死亡反应中rpr和hid之间的功能相互作用，并提供了证据，表明果蝇在细胞凋亡抑制剂1和rpr和之间的平衡中通过类固醇触发改变了变态过程中幼虫组织细胞死亡的确切时机。隐藏死亡激活剂。

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