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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Anteriorization of neural fate by inhibitor of beta-catenin and T cell factor (ICAT), a negative regulator of Wnt signaling.
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Anteriorization of neural fate by inhibitor of beta-catenin and T cell factor (ICAT), a negative regulator of Wnt signaling.

机译:β-catenin和T细胞因子(ICAT)抑制剂(Wnt信号的负调节剂)可抑制神经命运。

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摘要

Inhibitor of beta-catenin and T cell factor (ICAT) inhibits Wnt signaling by interfering with the interaction between beta-catenin and T cell factor. Here we show that ICAT(-/-) embryos exhibit malformation of the forebrain and craniofacial bones and lack the kidney. Analysis of the neuronal differentiation of embryonic stem cells revealed that Wnt3a redirects the fate of neural progenitors to a posterior character, whereas ICAT induces forebrain cells by inhibiting Wnt signaling. Furthermore, ICAT(-/-) embryonic stem cells were found to differentiate into neuronal cells possessing a posterior character. These results suggest that ICAT plays an important role in the anteriorization of neural cells by inhibiting the posteriorizing activity of Wnt signaling.
机译:β-catenin和T细胞因子的抑制剂(ICAT)通过干扰β-catenin和T细胞因子之间的相互作用来抑制Wnt信号传导。在这里,我们显示ICAT(-/-)胚胎展现出前脑和颅面骨骼的畸形,并且缺少肾脏。对胚胎干细胞神经元分化的分析表明,Wnt3a将神经祖细胞的命运重定向到后部特征,而ICAT通过抑制Wnt信号传导诱导前脑细胞。此外,发现ICAT(-/-)胚胎干细胞分化为具有后验特征的神经元细胞。这些结果表明,ICAT通过抑制Wnt信号传导的后趋活性在神经细胞的前趋中起重要作用。

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