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Mapping quantitative traits with random and with ascertained sibships

机译:用随机和确定的亲属关系绘制数量性状

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摘要

Use of a robust score statistic based on a variance components model to map quantitative trait loci in randomly sampled pedigrees is reviewed. Sibships ascertained through a single proband are discussed. Under a standard assumption of multivariate normality, two suggested methods of ascertainment correction are shown to be asymptotically equivalent when the number of sibships is large.
机译:审查了使用基于方差成分模型的稳健得分统计量来映射随机采样的谱系中的数量性状基因座。讨论了通过一个先证者确定的同胞关系。在多变量正态性的标准假设下,当同胞数量很大时,两种建议的确定性校正方法在渐近性上被证明是渐近等效的。

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