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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Activation of NF-κB and inhibition of p53-mediated apoptosis by API2 mucosa-associated lymphoid tissue 1 fusions promote oncogenesis
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Activation of NF-κB and inhibition of p53-mediated apoptosis by API2 mucosa-associated lymphoid tissue 1 fusions promote oncogenesis

机译：API2黏膜相关淋巴样组织1融合蛋白激活NF-κB并抑制p53介导的凋亡促进肿瘤发生

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摘要

Mucosa-associated lymphoid tissue (MALT) lymphoma is the most common extranodal lymphoid cell neoplasia; it frequently follows chronic bacteria-induced inflammation in various tissues. MALT lymphomas are characterized genetically by the t(11;18)(q21;q21) translocation, which yields chimeric transcripts encoding structurally distinct API2/MALT1 fusion proteins. In this study, we provide functional evidence for the contribution of API2/MALT1 fusion proteins to transformation of cells in culture by activating the NF-κB pathway through a RelB/p50 dimer. Using microchip gene expression analysis, we demonstrate that different forms of the API2/MALT1 proteins activate both unique and overlapping gene programs in cells. In addition to this genome reprogramming, expression of distinct API2/MALT1 fusion products inhibits DNA damage-induced, p53-mediated apoptosis in an NF-κB-dependent manner. Collectively, these data reveal previously unknown functional diversity among API2/MALT1 fusion products and their function in NF-κB signaling as it connects to the apoptotic program, a pathway with strong relevance to cancer. Furthermore, they provide evidence underlying the emerging role of the NF-κB signaling pathway in the inhibition of apoptosis.
机译：粘膜相关淋巴样组织（MALT）淋巴瘤是最常见的结外淋巴样细胞瘤。它经常伴随着慢性细菌引起的各种组织炎症。 MALT淋巴瘤的遗传特征是t（11; 18）（q21; q21）易位，可产生编码结构上不同的API2 / MALT1融合蛋白的嵌合转录本。在这项研究中，我们通过激活RelB / p50二聚体的NF-κB途径，为API2 / MALT1融合蛋白对培养细胞转化的贡献提供了功能性证​​据。使用微芯片基因表达分析，我们证明了不同形式的API2 / MALT1蛋白可以激活细胞中独特的和重叠的基因程序。除了进行基因组重编程外，不同的API2 / MALT1融合产物的表达还以NF-κB依赖性的方式抑制DNA损伤诱导的p53介导的细胞凋亡。总的来说，这些数据揭示了API2 / MALT1融合产物之间以前未知的功能多样性，以及它们在与凋亡程序（与癌症高度相关的途径）连接的NF-κB信号传导中的功能。此外，它们提供了在抑制细胞凋亡中潜在的NF-κB信号通路新作用的证据。

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