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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease.
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Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease.

机译:治疗性免疫可以保护帕金森氏病小鼠模型中的多巴胺能神经元。

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摘要

Degeneration of the nigrostriatal dopaminergic pathway, the hallmark of Parkinson's disease, can be recapitulated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated mice. Herein, we demonstrate that adoptive transfer of copolymer-1 immune cells to MPTP recipient mice leads to T cell accumulation within the substantia nigra pars compacta, suppression of microglial activation, and increased local expression of astrocyte-associated glial cell line-derived neurotrophic factor. This immunization strategy resulted in significant protection of nigrostriatal neurons against MPTP-induced neurodegeneration that was abrogated by depletion of donor T cells. Such vaccine treatment strategies may provide benefit for Parkinson's disease.
机译:帕金森氏病的标志性黑质纹状体多巴胺能途径的退化可以在1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)中毒的小鼠中概括。在本文中,我们证明了将共聚物1免疫细胞过继转移至MPTP受体小鼠会导致T细胞在黑质致密部内积聚,抑制小胶质细胞活化并增加星形胶质细胞相关神经胶质细胞源性神经营养因子的局部表达。这种免疫策略可显着保护黑质纹状体神经元免受MPTP诱导的神经变性的损害,该变性被供体T细胞的耗竭所消除。这样的疫苗治疗策略可以为帕金森氏病提供益处。

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