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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist.
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Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist.

机译：黑皮质素受体激动剂选择性促进雌性大鼠的性征。

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摘要

Disorders of sexual desire affect an estimated 30% of women in North America and Europe, with etiologies based on interpersonal, personal, and physiological factors. There are currently no pharmacological agents approved for use in the treatment of female sexual dysfunction. This is due, in part, to a focus on the effects of experimental drugs on reflexive components of sexual behavior, such as lordosis, in animal models. Here we report that PT-141, a peptide analogue of alpha-melanocyte-stimulating hormone that binds to central melanocortin receptors, selectively stimulates solicitational behaviors in the female rat. This occurs without affecting lordosis, pacing, or other sexual behaviors. PT-141 did not cause generalized motor activation, nor did it affect the perception of sexual reward. A selective pharmacological effect on appetitive sexual behavior in female rats has not been reported previously, and indicates that central melanocortin systems are important in the regulation of female sexual desire. Accordingly, PT-141 may be the first identified pharmacological agent with the capability to treat female sexual desire disorders.
机译：性欲障碍的病因基于人际，个人和生理因素，影响了北美和欧洲的30％妇女。目前尚无批准用于治疗女性性功能障碍的药物。这部分归因于对动物模型中实验药物对性行为反身成分（如前凸）的影响的关注。在这里我们报告PT-141，α-黑素细胞刺激激素的肽类似物，与中枢黑皮质素受体结合，选择性刺激雌性大鼠的招揽行为。发生这种情况不会影响脊柱前凸，起搏或其他性行为。 PT-141不会引起全身性的运动激活，也不会影响性奖励的感知。以前没有关于雌性大鼠食欲性行为的选择性药理作用的报道，这表明中枢黑皮质素系统在调节女性性欲中很重要。因此，PT-141可能是第一个被鉴定具有治疗女性性欲障碍能力的药物。

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