...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Learning modulates the ensemble representations for odors in primary olfactory networks.
【24h】

Learning modulates the ensemble representations for odors in primary olfactory networks.

机译：学习调制初级嗅觉网络中气味的整体表示。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recent evidence suggests that odor-driven responses in the insect antennal lobe (AL) can be modified by associative and nonassociative processes, as has been shown in the vertebrate olfactory bulb. However, the specific network changes that occur in response to olfactory learning remain unknown. To characterize changes in AL network activity during learning, we developed an in vivo protocol in Manduca sexta that allows continuous monitoring of neural ensembles and feeding behavior over the course of olfactory conditioning. Here, we show that Pavlovian conditioning produced a net recruitment of responsive neural units across the AL that persisted after conditioning. Recruitment only occurred when odor reliably predicted food. Conversely, when odor did not predict food, a net loss of responsive units occurred. Simultaneous measures of feeding responses indicated that the treatment-specific patterns of neural recruitment were positively correlated with changes in the insect's behavioral response to odor. In addition to recruitment, conditioning also produced consistent and profound shifts in the temporal responses of 16% of recorded units. These results show that odor representations in the AL are dynamic and related to olfactory memory consolidation. We furthermore provide evidence that the basis of the learning-dependent changes in the AL is not simply an increase in activity in the neural network representing an odorant. Rather, learning produces a restructuring of spatial and temporal components of network responses to odor in the AL.
机译：最近的证据表明，昆虫触角叶（AL）中气味驱动的反应可以通过缔合和非缔合过程进行修饰，如脊椎动物嗅球中所示。但是，响应嗅觉学习而发生的特定网络变化仍然未知。为了表征学习过程中AL网络活动的变化，我们开发了一种Manduca sexta体内实验方案，该方案允许在嗅觉调节过程中连续监测神经系统和进食行为。在这里，我们显示巴甫洛夫式调理产生了整个AL的反应性神经单元的净募集，而该条件在调理后仍然持续。只有在有气味可靠地预测食物时才进行招聘。相反，当气味不能预测食物时，就会出现反应单位的净损失。摄食反应的同时测量表明，特定的神经募集方式与昆虫对气味的行为反应的变化呈正相关。除了补充外，调节还使记录的单元的16％的时间响应产生了持续而深刻的变化。这些结果表明，AL中的气味表示是动态的，并且与嗅觉记忆巩固有关。我们进一步提供证据表明，AL中依赖于学习的变化的基础不仅仅是代表气味剂的神经网络中活性的增加。更确切地说，学习可以重新构造网络对AL中气味的响应的时空成分。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号