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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The SapB morphogen is a lantibiotic-like peptide derived from the product of the developmental gene ramS in Streptomyces coelicolor
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The SapB morphogen is a lantibiotic-like peptide derived from the product of the developmental gene ramS in Streptomyces coelicolor

机译：SapB形态发生原是一种类羊毛硫抗生素样肽，源于天蓝色链霉菌中发育基因ramS的产物

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摘要

SapB is a morphogenetic peptide that is important for aerial mycelium formation by the filamentous bacterium Streptomyces coelicolor. Production of SapB commences during aerial mycelium formation and depends on most of the genes known to be required for the morphogenesis of aerial hyphae. Furthermore, the application of purified SapB to mutants blocked in morphogenesis restores their capacity to form aerial hyphae. Here, we present evidence that SapB is a lantibiotic-like peptide that is derived by posttranslational modification from the product of a gene (ramS) in the four-gene ram operon, which is under the control of the regulatory gene ramR. We show that the product of another gene in the operon (ramC) contains a region that is similar to enzymes involved in the biosynthesis of lantibiotics, suggesting that it might be involved in the posttranslational processing of Rams. We conclude that SapB is derived from RamS through proteolytic cleavage and the introduction of four dehydroalanine residues and two lanthionine bridges. We provide an example of a morphogenetic role for an antibiotic-like molecule.
机译：SapB是一种形态发生肽，对于丝状细菌天生链霉菌气生菌丝形成非常重要。 SapB的生产在气生菌丝形成期间开始，并且取决于气生菌丝形态发生所需的大多数已知基因。此外，将纯化的SapB应用于在形态发生中受阻的突变体可恢复其形成气生菌丝的能力。在这里，我们提供的证据表明SapB是一种羊毛硫抗生素样肽，是通过翻译后修饰从四基因ram操纵子中一个调控基因ramR的四基因ram操纵子中的基因（ramS）产物衍生而来的。我们显示操纵子中另一个基因的产物（ramC）包含一个区域，该区域类似于参与羊毛硫抗生素生物合成的酶，这表明它可能参与了Rams的翻译后加工。我们得出的结论是，SapB是通过蛋白水解切割并引入四个脱氢丙氨酸残基和两个羊毛硫氨酸桥而从RamS衍生而来的。我们提供了一个类抗生素分子的形态发生作用的例子。

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