...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The membrane actions of estrogens can potentiate their lordosis behavior-facilitating genomic actions
【24h】

The membrane actions of estrogens can potentiate their lordosis behavior-facilitating genomic actions

机译：雌激素的膜作用可增强其脊柱前凸行为，促进基因组作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The membrane actions of estrogens can facilitate their genomic actions. To determine whether this facilitation bears on CNS mechanisms for estrogen-dependent behaviors, ovariectomized rats were subjected to a two-pulse treatment of estrogen directly in the hypothalamic ventromedial nucleus. Two days later, each rat was given progesterone and then tested for lordosis behavior, the induction of which requires the genomic actions of estrogen. When estrogen was given in both pulses (15 min to 2 h duration, and 5 h apart) lordosis was induced. Based on results from studies on neuroblastoma cells, we hypothesized that the membrane actions of estrogen in the first pulse would potentiate the genomic actions of estrogen in the second. This hypothesis was confirmed with the use of a membrane-impermeable estrogen. However, surprisingly, the order of the pulses could be reversed and still achieve lordosis behavior induction. Finally, activators of protein kinase A or PKC were effective substitutes for the membrane-limited pulse of estrogen. Thus, estrogen-induced membrane actions in the hypothalamus can potentiate its lordosis-inducing genomic actions on behavior and may be mediated by signaling pathways involving the activation of protein kinase A and PKC.
机译：雌激素的膜作用可促进其基因组作用。为了确定这种促进作用是否影响中枢神经系统依赖雌激素的行为的机制，将卵巢切除的大鼠直接在下丘脑腹膜外核中接受雌激素的两脉冲治疗。两天后，给每只大鼠服用孕酮，然后测试其脊柱前凸行为，其诱导需要雌激素的基因组作用。当两个脉冲中都注射雌激素时（持续时间15分钟至2小时，相隔5小时），则导致脊柱前凸。基于对神经母细胞瘤细胞研究的结果，我们假设在第一个脉冲中雌激素的膜作用将增强第二个脉冲中雌激素的基因组作用。使用膜不可渗透的雌激素证实了这一假设。但是，令人惊讶的是，脉冲的顺序可以颠倒并且仍然实现脊柱前凸行为的诱导。最后，蛋白激酶A或PKC的激活剂可以有效替代雌激素的膜受限脉冲。因此，下丘脑中雌激素诱导的膜作用可以增强其对行为的前凸病诱导基因组作用，并且可以由涉及蛋白激酶A和PKC活化的信号传导途径介导。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号