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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Spatial memory, recognition memory, and the hippocampus
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Spatial memory, recognition memory, and the hippocampus

机译：空间记忆，识别记忆和海马体

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摘要

There is wide agreement that spatial memory is dependent on the integrity of the hippocampus, but the importance of the hippocampus for nonspatial tasks, including tasks of object recognition memory is not as clear. We examined the relationship between hippocampal lesion size and both spatial memory and object recognition memory in rats. Spatial memory was impaired after bilateral dorsal hippocampal lesions that encompassed 30-50% total volume, and as lesion size increased from 50% to approximate to100% of total hippocampal volume, performance was similarly impaired. In contrast, object recognition was intact after dorsal hippocampal lesions that damaged 50-75% of total hippocampal volume and was impaired only after larger lesions that encompassed 75-100% of hippocampal volume. Last, ventral hippocampal lesions that encompassed approximate to50% of total hippocampal volume impaired spatial memory but did not affect object recognition memory. These findings show that the hippocampus is important for both spatial memory and recognition memory. However, spatial memory performance requires more hippocampal tissue than does recognition memory.
机译：人们普遍认为，空间记忆取决于海马的完整性，但是海马对于非空间任务（包括对象识别记忆的任务）的重要性尚不明确。我们检查了大鼠海马病变大小与空间记忆和对象识别记忆之间的关系。在占总体积30％至50％的双侧背侧海马损伤后，空间记忆受损，并且随着病变大小从50％增加到约占海马总体积的100％，性能也受到损害。相反，在海马背侧损伤破坏了海马总体积的50-75％之后，目标识别才完好无损，并且只有在涵盖海马体积的75-100％的较大损伤之后，对象识别才受损。最后，约占海马总体积50％的腹侧海马损伤损害了空间记忆，但没有影响物体识别记忆。这些发现表明，海马对于空间记忆和识别记忆都很重要。但是，空间记忆性能比识别记忆需要更多的海马组织。

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