• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Development of hydrocephalus in mice lacking SOCS7
【24h】

Development of hydrocephalus in mice lacking SOCS7

机译：缺乏SOCS7的小鼠脑积水的发展

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

SOCS7 is a member of the suppressor of cytokine signaling (SOCS) family of proteins (SOCS1-SOCS7 and CIS). SOCS proteins are composed of an N-terminal domain of variable length, a central Src homology 2 domain, and a C-terminal SOCS box. Biochemical and genetic studies have revealed that SOCS1, SOCS2, SOCS3, and CIS play an important role in the termination of cytokine and growth factor signaling. However, the biological actions of other SOCS proteins are less well defined. To investigate the physiological role of SOCS7, we have used gene targeting to generate mice that lack expression of the Socs7 gene. Socs7-/- mice were born in expected numbers, were fertile, and did not exhibit defects in hematopoiesis or circulating glucose or insulin concentrations. However, Socs7-/- mice were 7-10% smaller than their wild-type littermates, and within 15 weeks of age approximately 50% of the Socs7-/- mice died as a result of hydrocephalus that was characterized by cranial distortion, dilation of the ventricular system, reduced thickness of the cerebral cortex, and disorganization of the subcommissural organ. In situ hybridization studies revealed prominent expression of Socs7 in the brain, suggestive of an important functional role of SOCS7 in this organ.
机译：SOCS7是细胞因子信号传导（SOCS）蛋白家族（SOCS1-SOCS7和CIS）的抑制子。 SOCS蛋白由可变长度的N末端结构域，中央Src同源性2结构域和C末端SOCS框组成。生化和遗传研究表明，SOCS1，SOCS2，SOCS3和CIS在细胞因子和生长因子信号传导的终止中起重要作用。但是，其他SOCS蛋白的生物学作用尚不明确。为了研究SOCS7的生理作用，我们使用了基因靶向来产生缺乏Socs7基因表达的小鼠。 Socs7-/-小鼠以预期的数量出生，可以生育，并且在造血或循环葡萄糖或胰岛素浓度方面没有表现出缺陷。但是，Socs7-/-小鼠比野生型同窝小7-10％，在15周龄内，约有50％的Socs7-/-小鼠死于脑积水，其特点是颅骨变形，扩张的心室系统，大脑皮层的厚度减少和连合下器官的混乱。原位杂交研究揭示了Socs7在大脑中的显着表达，暗示了SOCS7在该器官中的重要功能作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号