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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >A biochemical oscillator explains several aspects of Myxococcus xanthus behavior during development.
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A biochemical oscillator explains several aspects of Myxococcus xanthus behavior during development.

机译：生化振荡器解释了在发展过程中黄原胶球菌行为的几个方面。

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摘要

During development, Myxococcus xanthus cells produce a series of spatial patterns by coordinating their motion through a contact-dependent signal, the C-signal. C-signaling modulates the frequency at which cells reverse their gliding direction. It does this by interacting with the Frz system (a homolog of the Escherichia coli chemosensory system) via a cascade of covalent modifications. Here we show that introducing a negative feedback into this cascade results in oscillatory behavior of the signaling circuit. The model explains several aspects of M. xanthus behavior during development, including the nonrandom distribution of reversal times, and the differences in response of the reversal frequency to both moderate and high levels of C-signaling at different developmental stages. We also propose experiments to test the model.
机译：在发育过程中，黄色粘球菌细胞通过接触相关信号C信号协调其运动，从而产生一系列空间模式。 C信号调制细胞反转其滑动方向的频率。它通过共价修饰的级联与Frz系统（大肠杆菌化学感应系统的同系物）相互作用来实现此目的。在这里，我们表明将负反馈引入该级联会导致信号电路的振荡行为。该模型解释了黄褐线虫在发育过程中行为的几个方面，包括逆转时间的非随机分布，以及在不同的发育阶段，逆转频率对中等和高水平C信号的响应差异。我们还建议进行实验以测试模型。

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