...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Antigen-independent memory CD8 T cells do not develop during chronic viral infection.
【24h】

Antigen-independent memory CD8 T cells do not develop during chronic viral infection.

机译：在慢性病毒感染期间不会产生抗原非依赖性记忆CD8 T细胞。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Memory T cells can persist for extended periods in the absence of antigen, and long-term T cell immunity is often seen after acute infections. Paradoxically, there have been observations suggesting that T cell memory may be antigen-dependent during chronic infections. To elucidate the underlying mechanisms we have compared memory CD8 T cell differentiation during an acute versus chronic infection by using the mouse model of infection with lymphocytic choriomeningitis virus. We found that during a chronic infection virus-specific CD8 T cells failed to acquire the cardinal memory T cell property of long-term antigen-independent persistence. These chronically stimulated CD8 T cells were unable to undergo homeostatic proliferation, responded poorly to IL-7 and IL-15, and expressed reduced levels of the IL-7 and IL-15 receptors, thus providing a possible mechanism for the inability of these cells to persist long term in the absence of antigen. In striking contrast, virus-specific memory CD8 T cells that developed after an acute lymphocytic choriomeningitis virus infection could persist without antigen, were capable of self-renewal because of homeostatic proliferation, responded efficiently to IL-7 and IL-15, and expressed high levels of receptors for these two cytokines. Thus, memory CD8 T cells generated after acute infections are likely to have a competitive advantage over CD8 T cells that develop during chronic infections. These findings raise concerns about using vaccines that may persist and also suggest that there may be limitations and challenges in designing effective immunological interventions for the treatment of chronic infections and tumors.
机译：在没有抗原的情况下，记忆T细胞可以持续较长时间，急性感染后通常可以看到长期T细胞免疫。矛盾的是，有观察表明在慢性感染期间T细胞记忆可能是抗原依赖性的。为了阐明潜在的机制，我们通过使用淋巴细胞性脉络膜脑膜炎病毒感染的小鼠模型比较了急性和慢性感染期间的记忆CD8 T细胞分化。我们发现，在慢性感染期间，病毒特异性CD8 T细胞无法获得长期的抗原非依赖性持久性的基本记忆T细胞特性。这些慢性刺激的CD8 T细胞无法进行稳态增殖，对IL-7和IL-15的反应较差，并且IL-7和IL-15受体的表达水平降低，因此为这些细胞的失活提供了可能的机制在没有抗原的情况下可以长期持续。与之形成鲜明对比的是，急性淋巴细胞性脉络膜脑膜炎病毒感染后形成的病毒特异性记忆CD8 T细胞可以持续存在而没有抗原，由于体内稳态增殖而具有自我更新的能力，对IL-7和IL-15有效反应，并高表达。这两种细胞因子的受体水平。因此，急性感染后产生的记忆CD8 T细胞可能比慢性感染过程中形成的CD8 T细胞具有竞争优势。这些发现引起了人们对使用可能持续存在的疫苗的担忧，也表明在设计用于治疗慢性感染和肿瘤的有效免疫干预措施方面可能存在局限性和挑战性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号