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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Local modulation of plus-end transport targets herpesvirus entry and egress in sensory axons.
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Local modulation of plus-end transport targets herpesvirus entry and egress in sensory axons.

机译：正向转运的局部调节以疱疹病毒进入和流出感觉轴突为目标。

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摘要

The core structures of many viruses move within cells by association with host cytoskeletal motor proteins; however, the mechanisms by which intracellular viral particles are transported toward sites of replication or the cell periphery at distinct stages of infection remain to be understood. The regulation of herpesvirus directional transport in sensory neurons was examined by tracking individual viral capsids within axons at multiple frames per s. After entry into axons, capsids underwent bidirectional and saltatory movement to the cell body independently of endosomes. A comparison of entry transport to a previous analysis of capsid axonal transport during egress revealed that capsid targeting in and out of cells occurs by modulation of plus-end, but not minus-end, motion. Entry transport was unperturbed by the presence of egressing virus from a prior infection, indicating that transport direction is not modulated globally by viral gene expression, but rather directly by a component of the viral particle.
机译：许多病毒的核心结构是通过与宿主细胞骨架运动蛋白结合而在细胞内移动的。然而，细胞内病毒颗粒在感染的不同阶段向复制位点或细胞外围转运的机制仍有待了解。通过追踪轴突内单个病毒衣壳，以每秒钟多个帧的速度检查疱疹病毒在感觉神经元中的定向转运。进入轴突后，衣壳独立于内体进行双向和盐碱化运动至细胞体。将进入运输与出口期间衣壳轴突运输的先前分析进行比较，发现衣壳靶向进出细胞是通过调节正向运动而不是负向运动来实现的。进入的运输不受先前感染中流出病毒的干扰，表明运输方向不受病毒基因表达的调节，而直接受病毒颗粒成分的调节。

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