...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Inorganic polyphosphate in the origin and survival of species.
【24h】

Inorganic polyphosphate in the origin and survival of species.

机译：无机多磷酸盐的起源和生存种类。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Inorganic polyphosphate (poly P), in chains of tens to hundreds of phosphate residues, linked by high-energy bonds, is environmentally ubiquitous and abundant. In prebiotic evolution it could have provided a flexible, polyanionic scaffold to assemble macromolecules. It has been conserved in every cell in nature. In prokaryotes, a major poly P synthetic enzyme is poly P kinase 1 (PPK1), which is found in 100 bacterial genomes, including numerous pathogens. Null mutants of PPK1, with low poly P levels, are defective in survival: namely, they show defective responses to physical/chemical stresses and predation. Pathogens with a PPK1 deletion are defective in biofilm formation, quorum sensing, general stress and stringent responses, motility, and other virulence properties. With the exception of Dictyostelium, PPK1 is absent in eukaryotes and provides a novel target for chemotherapy that would affect both virulence and susceptibility to antibacterial compounds. Remarkably, another PPK in Dictyostelium discoideum (PPK2) is an actin-related protein (Arp) complex that is polymerized into an actin-like filament, concurrent with its reversible synthesis of a poly P chain from ATP.
机译：通过高能键连接的数十至数百个磷酸残基链中的无机多磷酸盐（poly P）在环境上无处不在且丰富。在益生元的进化中，它可能提供了一种柔性的聚阴离子支架来组装大分子。它在自然界的每个细胞中都得到了保存。在原核生物中，主要的聚P合成酶是聚P激酶1（PPK1），存在于100个细菌基因组中，包括许多病原体。具有低聚P水平的PPK1空突变体在生存方面存在缺陷：即，它们对物理/化学应激和捕食显示出不良的响应。具有PPK1缺失的病原体在生物膜形成，群体感应，一般压力和严格反应，运动性和其他毒力特性方面存在缺陷。除双歧杆菌外，真核生物中不存在PPK1，它为化学疗法提供了新的靶标，既会影响毒力又对抗菌化合物易感。值得注意的是，盘基网柄菌（PPK2）中的另一种PPK是肌动蛋白相关蛋白（Arp）复合物，聚合成肌动蛋白样细丝，同时可逆地由ATP合成多聚P链。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号