Genes required for Drosophila nervous system development identified by RNA interference.

Ivanov AI; Rovescalli AC; Pozzi P; Yoo S; Mozer B; Li HP; Yu SH; Higashida H; Guo V; Spencer M; Nirenberg M

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Genes required for Drosophila nervous system development identified by RNA interference.

机译：果蝇神经系统发育所需的基因通过RNA干扰鉴定。

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RNA interference was used to screen 3,314 Drosophila double-stranded RNAs, corresponding to approximately 25% of Drosophila genes, for genes that affect the development of the embryonic nervous system. RNA-interference-mediated gene silencing in Drosophila embryos resulted in loss-of-function mutant phenotypes for 43 genes, which is 1.3% of the genes that were screened. We found 18 genes that were not known previously to affect the development of the nervous system. The functions of some of the genes are unknown. Other genes encode protein kinases, transcription factors, and signaling proteins, as well as proteins with other functions.

机译：RNA干扰用于筛选影响胚胎神经系统发育的基因的3,314个果蝇双链RNA，约占果蝇基因的25％。果蝇胚胎中RNA干扰介导的基因沉默导致43个基因的功能丧失突变表型，这是所筛选基因的1.3％。我们发现了18个以前不知道会影响神经系统发育的基因。一些基因的功能未知。其他基因编码蛋白激酶，转录因子和信号蛋白，以及具有其他功能的蛋白。

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2004年第46期|P.16216-16221|共6页
作者
Ivanov AI; Rovescalli AC; Pozzi P; Yoo S; Mozer B; Li HP; Yu SH; Higashida H; Guo V; Spencer M; Nirenberg M;
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作者单位

Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
Drosophila melanogaster; Genes; Insect; Nervous System; RNA Interference; 果蝇; 黑腹; 基因; 昆虫; 神经系统;

机译：Drosophila melanogaster;Genes;Insect;Nervous System;RNA Interference;果蝇;黑腹;基因;昆虫;神经系统;

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2. Essential role of grim-led programmed cell death for the establishment of corazonin-producing peptidergic nervous system during embryogenesis and metamorphosis in Drosophila melanogaster Essential role of grim-led programmed cell death for the establishment of corazonin-producing peptidergic nervous system during embryogenesis and metamorphosis in Drosophila melanogaster Essential role of grim-led programmed cell death for the establishment of corazonin-producing peptidergic nervous system during embryogenesis and metamorphosis in Drosophila melanogaster [J] . Zixing Wang, Jae H. Park, Chun-Hong Chen, Biology Open . 2013,第3期

机译：严峻的程序性细胞死亡在果蝇胚胎发生和变态过程中建立corazonin产生的肽能神经系统中的重要作用严峻的程序性细胞死亡在果蝇的胚胎发生和变形过程中建立corazonin产生的肽能神经系统中的重要作用。果蝇致死的程序性细胞死亡在果蝇胚胎发生和变态过程中建立可乐宁生产肽能神经系统的建立中的重要作用
3. The purine synthesis gene Prat2 is required for Drosophila metamorphosis, as revealed by inverted-repeat-mediated RNA interference. [J] . Ji Y, Clark DV Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 2006,第3期

机译：嘌呤合成基因Prat2是果蝇变态所必需的，这是通过反向重复介导的RNA干扰揭示的。
4. microRNAs in CNS Development and Neurodegeneration: Insights from Drosophila Genetics [C] . Stephen M. Cohen Colloque me?decine et recherche . 2010

机译：CNS开发和神经变性的MicroRNA：来自果蝇遗传学的见解
5. Theelav gene of Drosophila melanogaster encodes a neuron-specific RNA binding protein which is required for the development and maintenance of the nervous system [D] . Robinow, Steven Neal 1990

机译：果蝇的Theelav基因编码神经元特异性RNA结合蛋白，这是神经系统发育和维持所必需的
6. RNA interference screen to identify genes required for Drosophila embryonic nervous system development [O] . Keita Koizumi, Haruhiro Higashida, Siuk Yoo, 2007

机译：RNA干扰筛选可鉴定果蝇胚胎神经系统发育所需的基因
7. RNA interference screen to identify genes required for Drosophila embryonic nervous system development [O] . Koizumi, Keita, Higashida, Haruhiro, Yoo, Siuk, 2007

机译：RNA干扰筛选可鉴定果蝇胚胎神经系统发育所需的基因

Genes required for Drosophila nervous system development identified by RNA interference.

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