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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Reversible transdifferentiation of secretory epithelial cells into adipocytes in the mammary gland
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Reversible transdifferentiation of secretory epithelial cells into adipocytes in the mammary gland

机译：分泌性上皮细胞可逆转分化为乳腺中的脂肪细胞

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摘要

Mammalian breast adipose tissue is replaced by a milk-secreting gland during pregnancy; the reverse process takes place upon interruption of lactation. Morphological and bromodeoxyuridine studies provide indirect evidence that mouse mammary adipocytes transform into secretory epithelial cells during pregnancy and revert to adipocytes after lactation. By using the Cre-loxP recombination system we show that the mammary gland of whey acidic protein (WAP)-Cre/R26R mice, in which secretory epithelial cells express the lacZ gene during pregnancy, contains labeled adipocytes during involution. Conversely, adipocyte P2-Cre/R26R mice, in which adipocytes are labeled before pregnancy, contain labeled secretory epithelial cells during pregnancy. We conclude that reversible adipocyte-to-epithelium and epithelium-to-adipocyte transdifferentiation occurs in the mammary gland of adult mice during pregnancy and lactation.
机译：哺乳动物的乳房脂肪组织在怀孕期间被分泌乳汁的腺体所替代；当哺乳中断时发生逆过程。形态学和溴脱氧尿苷的研究提供了间接证据，表明小鼠乳腺脂肪细胞在怀孕期间转化为分泌性上皮细胞，并在泌乳后恢复为脂肪细胞。通过使用Cre-loxP重组系统，我们显示了乳清酸性蛋白（WAP）-Cre / R26R小鼠的乳腺，其中分泌的上皮细胞在怀孕期间表达lacZ基因，在进化过程中包含标记的脂肪细胞。相反，在怀孕前已标记脂肪细胞的脂肪细胞P2-Cre / R26R小鼠在怀孕期间含有标记的分泌性上皮细胞。我们得出的结论是，成年小鼠的乳腺在妊娠和哺乳期间发生可逆的脂肪细胞向上皮细胞和上皮细胞向脂肪细胞的转分化。

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