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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Microevolution and history of the plague bacillus, Yersinia pestis.
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Microevolution and history of the plague bacillus, Yersinia pestis.

机译：鼠疫耶尔森菌鼠疫杆菌的微进化和历史。

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摘要

The association of historical plague pandemics with Yersinia pestis remains controversial, partly because the evolutionary history of this largely monomorphic bacterium was unknown. The microevolution of Y. pestis was therefore investigated by three different multilocus molecular methods, targeting genomewide synonymous SNPs, variation in number of tandem repeats, and insertion of IS100 insertion elements. Eight populations were recognized by the three methods, and we propose an evolutionary tree for these populations, rooted on Yersinia pseudotuberculosis. The tree invokes microevolution over millennia, during which enzootic pestoides isolates evolved. This initial phase was followed by a binary split 6,500 years ago, which led to populations that are more frequently associated with human disease. These populations do not correspond directly to classical biovars that are based on phenotypic properties. Thus, we recommend that henceforth groupings should be based on molecular signatures. The age of Y. pestis inferred here is compatible with the dates of historical pandemic plague. However, it is premature to infer an association between any modern molecular grouping and a particular pandemic wave that occurred before the 20th century.
机译：历史鼠疫大流行与鼠疫耶尔森氏菌的关联仍存在争议，部分原因是这种很大程度上单态细菌的进化史尚不清楚。因此，通过三种不同的多基因座分子方法研究了鼠疫耶尔森氏菌的微进化，这些方法针对全基因组同义SNP，串联重复数目的变化以及IS100插入元件的插入。三种方法可识别8个种群，我们针对这些种群提出了一种进化树，其根植于耶尔森氏假结核。该树引发了数千年的微进化，在此期间进化出了香豆菌分离株。这个初始阶段之后是6,500年前的二元分裂，这导致了与人类疾病相关的人群更加频繁。这些种群并不直接对应于基于表型特性的经典生物变种。因此，我们建议以后的分组应基于分子标记。此处推断的鼠疫耶尔森氏菌年龄与大流行性瘟疫的历史相吻合。但是，推断任何现代分子群与20世纪之前发生的特定流行病之间的联系还为时过早。

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