...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Endogenous circadian rhythm in an index of cardiac vulnerability independent of changes in behavior.
【24h】

Endogenous circadian rhythm in an index of cardiac vulnerability independent of changes in behavior.

机译：内源性昼夜节律是独立于行为变化的心脏易损性指标。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

There exists a robust dayight pattern in the incidence of adverse cardiac events with a peak at approximately 10 a.m. This peak traditionally has been attributed to dayight patterns in behaviors affecting cardiac function in vulnerable individuals. However, influences from the endogenous circadian pacemaker independent from behaviors may also affect cardiac control. Heartbeat dynamics under healthy conditions exhibit robust complex fluctuations characterized by self-similar temporal structures, which break down under pathologic conditions. We hypothesize that these dynamical features of the healthy human heartbeat have an endogenous circadian rhythm that brings the features closer to those observed under pathologic conditions at the endogenous circadian phase corresponding to approximately 10 a.m. We investigate heartbeat dynamics in healthy subjects recorded throughout a 10-day protocol wherein the sleep/wake and behavior cycles are desynchronized from the endogenous circadian cycle, enabling assessment of circadian factors while controlling for behavior-related factors. We demonstrate that the scaling exponent characterizing temporal correlations in heartbeat dynamics does exhibit a significant circadian rhythm (with a sharp peak at the circadian phase corresponding to approximately 10 a.m.), which is independent from scheduled behaviors and mean heart rate. Cardiac dynamics under pathologic conditions such as congestive heart failure also are associated with a larger value of the scaling exponent of the interbeat interval. Thus, the sharp peak in the scaling exponent at the circadian phase coinciding with the period of highest cardiac vulnerability observed in epidemiological studies suggests that endogenous circadian-mediated influences on cardiac control may be involved in the dayight pattern of adverse cardiac events in vulnerable individuals.
机译：不良心脏事件的发生存在稳健的昼/夜模式，其峰值约为上午10点。传统上，该峰值归因于影响易受攻击者心脏功能的行为的昼/夜模式。但是，不受行为影响的内源性昼夜节律起搏器的影响也可能影响心脏控制。健康条件下的心跳动力学表现出强大的复杂波动，其特征是自相似的时间结构，在病理条件下会分解。我们假设健康的人心跳的这些动力学特征具有内生的昼夜节律，使这些特征更接近于在病理条件下在对应于大约上午10点的内生昼夜节律下观察到的特征。我们调查了整个10天记录的健康受试者的心跳动力学协议，其中睡眠/唤醒和行为周期与内源性昼夜节律周期不同步，从而能够在控制行为相关因素的同时评估昼夜节律因素。我们证明了表征心跳动力学中时间相关性的缩放指数确实表现出显着的昼夜节律（在昼夜节律阶段有一个急剧的峰值对应于大约上午10点），这与计划的行为和平均心率无关。诸如充血性心力衰竭等病理状况下的心脏动力学也与心跳间隔的比例指数的较大值相关。因此，在流行病学研究中观察到的昼夜节律比例指数的尖峰与心脏最高脆弱期相吻合，这表明内源性昼夜节律对心脏控制的影响可能参与了易感人群中不良心脏事件的日/夜模式。个人。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号