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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Golgi inheritance in small buds of Saccharomyces cerevisiae is linked to endoplasmic reticulum inheritance
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Golgi inheritance in small buds of Saccharomyces cerevisiae is linked to endoplasmic reticulum inheritance

机译：酿酒酵母小芽中的高尔基遗传与内质网遗传有关

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摘要

According to the cisternal maturation hypothesis, endoplasmic reticulum (ER)-derived membranes nucleate new Golgi cisternae. The yeast Saccharomyces cerevisiae offers a unique opportunity to test this idea because small buds contain both ER and Golgi structures early in the cell cycle. We previously predicted that mutants defective in ER inheritance also would show defects in Golgi inheritance. Surprisingly, studies of S. cerevisiae have not revealed the expected link between ER and Golgi inheritance. Here, we revisit this issue by generating mutant strains in which many of the small buds are devoid of detectable ER. These strains also show defects in the inheritance of both early and late Golgi cisternae. Strikingly, virtually all of the buds that lack ER also lack early Golgi cisternae. Our results fit with the idea that membranes exported from the ER coalesce with vesicles derived from existing Golgi compartments to generate new Golgi cisternae. This basic mechanism of Golgi inheritance may be conserved from yeast to vertebrate cells.
机译：根据脑池成熟假说，内质网（ER）衍生的膜可形成新的高尔基池。酵母酿酒酵母提供了一个独特的机会来检验这一想法，因为小芽在细胞周期的早期就同时含有内质网和高尔基体。我们以前曾预测，ER遗传缺陷的突变体也会在高尔基遗传中显示缺陷。令人惊讶的是，对酿酒酵母的研究并未揭示内质网与高尔基体遗传之间的预期联系。在这里，我们通过产生突变株重新审视这个问题，在突变株中，许多小芽都没有可检测的ER。这些菌株还显示出早期和晚期高尔基池的遗传缺陷。令人惊讶的是，几乎所有缺乏ER的芽也缺乏早期的高尔基水箱。我们的结果符合这样一种想法，即从ER出口的膜与从现有高尔基体隔室衍生的囊泡合并以生成新的高尔基水箱。从酵母菌到脊椎动物细胞，高尔基体遗传的这种基本机制可能是保守的。

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