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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Specific antigen vaccination to treat autoimmune disease
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Specific antigen vaccination to treat autoimmune disease

机译：特异性抗原疫苗治疗自身免疫性疾病

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Specific antigen vaccination by administration of the target antigen in aqueous solution has resulted in significant decreases of disease severity in animal models of experimental allergic enceph-alomyelitis, type I diabetes, and several forms of antigen-induced arthritis, even if administered after the initiation of symptoms. However, in experimental autoimmune encephalomyelitis (EAE) and type I diabetes in nonobese diabetic (NOD) mice, repeated administration of peptide fragments of target antigens in incomplete Freund's adjuvant has resulted in severe anaphylactic reactions. Although these methods of administration are known to potentiate CD4 T helper 2 (Th2) responses, which is the goal of specific antigen vaccination, the risk of anaphylaxis raises a red flag concerning use of this therapy for diseases such as type I diabetes, where the survival time after onset is quite long. It is clear that specific antigen vaccination is effective in preventing several animal models of autoimmune disease, and in treating these diseases once the symptoms are overt. However, the risks of this therapy require serious consideration of alternative methods for down-regulation of the autoimmune process.
机译：在实验性变应性脑脊髓炎，I型糖尿病和几种形式的抗原诱导的关节炎的动物模型中，即使在感染后开始施用靶抗原，也要通过在水溶液中施用靶抗原来进行特异性抗原接种，从而导致疾病严重程度的显着降低。症状。但是，在非肥胖糖尿病（NOD）小鼠的实验性自身免疫性脑脊髓炎（EAE）和I型糖尿病中，在不完全的弗氏佐剂中重复施用靶抗原的肽片段会导致严重的过敏反应。尽管已知这些给药方法可增强CD4 T辅助2（Th2）的应答，这是特异性抗原疫苗接种的目标，但发生过敏反应的风险使该疗法用于I型糖尿病等疾病时产生了危险。发病后的生存时间相当长。显然，特异性抗原疫苗接种可有效预防几种自身免疫性疾病的动物模型，并在症状明显后可治疗这些疾病。然而，这种疗法的风险需要认真考虑用于下调自身免疫过程的替代方法。

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