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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Role of ABC transporters in secretion of cholesterol from liver into bile
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Role of ABC transporters in secretion of cholesterol from liver into bile

机译：ABC转运蛋白在胆固醇从肝脏分泌到胆汁中的作用

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By 1968, the basic principles underlying cholesterol solubility in bile had been established. Free cholesterol (C) had been found to be almost entirely insoluble in water and very poorly soluble in bile salt solutions. Cholesterol was however very soluble in phosphotidylcholine (PC) lamellar liquid crystals (bilayers), and bile salts could solubilize the PC/C liquid crystal bilayers into mixed micelles, thus carrying the C into solution. In 1970, I speculated that the molecular mechanism for biliary lipid secretion was "that bile salts penetrate the cannilicular membrane from the interior of the liver cell and dissect out specifically lecithin and cholesterol leaving the membrane protein and other structural lipids intact." This hypothesis, based on the physical chemistry of the lipid systems, has now been proven to be almost entirely incorrect. It is now clear that all biliary lipids are secreted in a controlled way by ABC transporters, and that the physical chemistry of the lipid interactions probably occurs within the lumen of the canniliculus and biliary ducts.
机译：到1968年，已经确立了胆汁中胆固醇溶解度的基本原理。已发现游离胆固醇（C）几乎完全不溶于水，而在胆盐溶液中的溶解性极差。但是，胆固醇在磷脂酰胆碱（PC）层状液晶（双层）中非常易溶，并且胆汁盐可以将PC / C液晶双层溶解成混合胶束，从而将C带入溶液中。 1970年，我推测胆汁脂质分泌的分子机制是“胆汁盐从肝细胞内部渗入导管膜，并特异性地分解卵磷脂和胆固醇，而使膜蛋白和其他结构脂质完好无损。”基于脂质系统物理化学的这一假设现已被证明几乎是完全错误的。现在很清楚，所有胆汁脂质都是由ABC转运蛋白以受控方式分泌的，并且脂质相互作用的物理化学可能发生在套管和胆管腔内。

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