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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Color and genomic ancestry in Brazilians
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Color and genomic ancestry in Brazilians

机译：巴西人的颜色和基因组血统

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This work was undertaken to ascertain to what degree the physical appearance of a Brazilian individual was predictive of genomic African ancestry. Using a panel of 10 population-specific alleles, we assigned to each person an African ancestry index (AAI). The procedure was able to tell apart, with no overlaps, 20 males from northern Portugal from 20 males from Sao Tome Island on the west coast of Africa. We also tested 10 Brazilian Amerindians and observed that their AAI values fell in the same range as the Europeans. Finally, we studied two different Brazilian population samples. The first consisted of 173 individuals from a rural Southeastern community, clinically classified according to their Color (white, black, or intermediate) with a multivariate evaluation based on skin pigmentation in the medial part of the arm, hair color and texture, and the shape of the nose and lips. In contrast to the clear-cut results with the African and European samples, our results showed large variances and extensive overlaps among the three Color categories. We next embarked on a study of 200 unrelated Brazilian white males who originated from cosmopolitan centers of the four major geographic regions of the country. The results showed AAI values intermediate between Europeans and Africans, even in southern Brazil, a region predominantly peopled by European immigrants. Our data suggest that in Brazil, at an individual level, color, as determined by physical evaluation, is a poor predictor of genomic African ancestry, estimated by molecular markers. [References: 35]
机译：进行这项工作是为了确定巴西人的外表在多大程度上预示了非洲基因组的起源。我们使用10个特定人群的等位基因，为每个人分配了一个非洲血统指数（AAI）。该程序能够毫无区别地分辨出来自葡萄牙北部的20名男性和来自非洲西海岸圣多美岛的20名男性。我们还测试了10名巴西美洲印第安人，发现他们的AAI值与欧洲人处于同一范围内。最后，我们研究了两个不同的巴西人口样本。第一个样本由来自东南农村社区的173个人组成，根据其颜色（白色，黑色或中级）在临床上进行了分类，并根据手臂中部的皮肤色素沉着，头发的颜色和质地以及形状对其进行了多变量评估鼻子和嘴唇。与非洲和欧洲样本的清晰结果相反，我们的结果显示三种颜色类别之间存在较大差异和广泛重叠。接下来，我们开始对200位无关的巴西白人男性进行研究，这些男性来自该国四个主要地理区域的大都会中心。结果显示，即使在巴西南部（主要是欧洲移民所居住的地区），AAI值也介于欧洲人和非洲人之间。我们的数据表明，在巴西，通过个体评估，通过分子标记估计的颜色，不能很好地预测非洲基因组的祖先基因组。 [参考：35]

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