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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Functional connectivity in the resting brain: A network analysis of the default mode hypothesis
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Functional connectivity in the resting brain: A network analysis of the default mode hypothesis

机译：静息大脑中的功能连通性：默认模式假设的网络分析

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Functional imaging studies have shown that certain brain regions, including posterior cingulate cortex (PCC) and ventral anterior cingulate cortex (vACC), consistently show greater activity during resting states than during cognitive tasks. This finding led to the hypothesis that these regions constitute a network supporting a default mode of brain function. In this study, we investigate three questions pertaining to this hypothesis: Does such a resting-state network exist in the human brain? Is it modulated during simple sensory processing? How is it modulated during cognitive processing? To address these questions, we defined PCC and vACC regions that showed decreased activity during a cognitive (working memory) task, then examined their functional connectivity during rest. PCC was strongly coupled with vACC and several other brain regions implicated in the default mode network. Next, we examined the functional connectivity of PCC and vACC during a visual processing task and show that the resultant connectivity maps are virtually identical to those obtained during rest. Last, we defined three lateral prefrontal regions showing increased activity during the cognitive task and examined their resting-state connectivity. We report significant inverse correlations among all three lateral prefrontal regions and PCC, suggesting a mechanism for attenuation of default mode network activity during cognitive processing. This study constitutes, to our knowledge, the first resting-state connectivity analysis of the default mode and provides the most compelling evidence to date for the existence of a cohesive default mode network. Our findings also provide insight into how this network is modulated by task demands and what functions it might subserve. [References: 46]
机译：功能成像研究表明，某些大脑区域，包括后扣带回皮层（PCC）和腹侧扣带回前皮层（vACC），在静止状态下始终表现出比认知任务更大的活动。这一发现导致以下假设：这些区域构成了支持默认脑功能模式的网络。在这项研究中，我们调查了与该假设有关的三个问题：人脑中是否存在这样的静止状态网络？在简单的感官加工过程中会对其进行调制吗？在认知过程中如何对其进行调制？为了解决这些问题，我们定义了PCC和vACC区域，这些区域在认知（工作记忆）任务期间显示活动减少，然后在休息期间检查它们的功能连接性。 PCC与vACC和默认模式网络中牵连的其他几个大脑区域紧密耦合。接下来，我们在视觉处理任务期间检查了PCC和vACC的功能连通性，并显示了所得的连通性图实际上与休息时获得的连通性图相同。最后，我们定义了三个侧前额叶区域，这些区域在认知任务期间显示出增加的活动，并检查了它们的静息状态连通性。我们报告了所有三个横向前额叶区域和PCC之间的显着逆相关性，暗示了认知处理过程中默认模式网络活动衰减的机制。就我们所知，该研究构成了默认模式的第一个静止状态连接分析，并提供了迄今为止最有力的证据，证明了内聚默认模式网络的存在。我们的发现还可以洞悉任务需求如何调节该网络以及该网络可以提供的功能。 [参考：46]

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