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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Regulated subset of G1 growth-control genes in response to derepression by the Wnt pathway.
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Regulated subset of G1 growth-control genes in response to derepression by the Wnt pathway.

机译：Gnt生长控制基因的受调控子集，可响应Wnt通路的抑制作用。

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摘要

Pitx2 is a bicoid-related homeodomain factor that is required for effective cell type-specific proliferation directly activating a specific growth-regulating gene cyclin D2. Here, we report that Pitx2, in response to the Wntbeta-catenin pathway and growth signals, also can regulate c-Myc and cyclin D1. Investigation of molecular mechanisms required for Pitx2-dependent proliferation, in these cases, further supports a nuclear role for beta-catenin in preventing the histone deacetylase 1-dependent inhibitory functions of several DNA-binding transcriptional repressors, potentially including E2F4p130 pocket protein inhibitory complex, as well as lymphoid enhancer factor 1 and Pitx2, by dismissal of histone deacetylase 1 and loss of its enzymatic activity. Thus, beta-catenin plays a signal-integrating role in Wnt- and growth factor-dependent proliferation events in mammalian development by both derepressing several classes of repressors and by activating Pitx2, regulating the activity of several growth control genes.
机译：Pitx2是与二倍体相关的同源域因子，是直接激活特定生长调节基因细胞周期蛋白D2的有效细胞类型特异性增殖所必需的。在这里，我们报告Pitx2，响应Wntbeta-catenin途径和生长信号，也可以调节c-Myc和cyclin D1。在这些情况下，对Pitx2依赖性增殖所需的分子机制的研究进一步支持了β-catenin在防止几种DNA结合转录阻遏物（可能包括E2F4p130口袋蛋白抑制复合物）的组蛋白脱乙酰基酶1依赖性抑制功能中的核作用，以及通过去除组蛋白脱乙酰基酶1并丧失其酶活性而导致淋巴增强因子1和Pitx2。因此，β-catenin在哺乳动物发育中的Wnt和生长因子依赖性增殖事件中起着信号整合的作用，它既可以抑制多种类型的阻遏物，又可以激活Pitx2，调节几种生长控制基因的活性。

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