Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse.

Wiltshire T; Pletcher MT; Batalov S; Barnes SW; Tarantino LM; Cooke MP; Wu H; Smylie K; Santrosyan A; Copeland NG; Jenkins NA; Kalush F; Mural RJ; Glynne RJ; Kay SA; Adams MD; Fletcher CF

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Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse.

机译：全基因组单核苷酸多态性分析定义了小鼠中的单倍型模式。

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The nature and organization of polymorphisms, or differences, between genomes of individuals are of great interest, because these variations can be associated with or even underlie phenotypic traits, including disease susceptibility. To gain insight into the genetic and evolutionary factors influencing such biological variation, we have examined the arrangement (haplotype) of single-nucleotide polymorphisms across the genomes of eight inbred strains of mice. These analyses define blocks of high or low diversity, often extending across tens of megabases that are delineated by abrupt transitions. These observations provide a striking contrast to the haplotype structure of the human genome.

机译：个体基因组之间多态性的性质和组织，或差异，引起了极大的兴趣，因为这些变异可能与表型性状相关，甚至是其基础，包括疾病易感性。为了深入了解影响这种生物学变异的遗传和进化因素，我们检查了八种自交系小鼠基因组中单核苷酸多态性的排列（单倍型）。这些分析定义了高或低多样性的区块，通常跨越数十个兆碱基，这些兆碱基被突然的转变所描绘。这些观察结果与人类基因组的单倍型结构形成了鲜明的对比。

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2003年第6期|P.3380-3385|共6页
作者
Wiltshire T; Pletcher MT; Batalov S; Barnes SW; Tarantino LM; Cooke MP; Wu H; Smylie K; Santrosyan A; Copeland NG; Jenkins NA; Kalush F; Mural RJ; Glynne RJ; Kay SA; Adams MD; Fletcher CF;
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作者单位

Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA. timw@gnf.org;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Polymorphism; Single Nucleotide;

机译：多态性单核苷酸;

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6. Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse [O] . Tim Wiltshire, Mathew T. Pletcher, Serge Batalov, 2003

机译：全基因组单核苷酸多态性分析定义了小鼠的单倍型模式
7. Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse [O] . Wiltshire, Tim, Pletcher, Mathew T., Batalov, Serge, 2003

机译：全基因组单核苷酸多态性分析定义了小鼠的单倍型模式

Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse.

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