Dispersal of NK homeobox gene clusters in amphioxus and humans.

Luke GN; Castro LF; McLay K; Bird C; Coulson A; Holland PW

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Dispersal of NK homeobox gene clusters in amphioxus and humans.

机译：在两栖类和人类中NK同源异型盒基因簇的分散。

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摘要

The Drosophila melanogaster genome has six physically clustered NK-related homeobox genes in just 180 kb. Here we show that the NK homeobox gene cluster was an ancient feature of bilaterian animal genomes, but has been secondarily split in chordate ancestry. The NK homeobox gene clusters of amphioxus and vertebrates are each split and dispersed at two equivalent intergenic positions. From the ancestral NK gene cluster, only the Tlx-Lbx and NK3-NK4 linkages have been retained in chordates. This evolutionary pattern is in marked contrast to the Hox and ParaHox gene clusters, which are compact in amphioxus and vertebrates, but have been disrupted in Drosophila.

机译：果蝇（Drosophila melanogaster）基因组在仅仅180 kb的范围内有6个物理聚簇的NK相关同源盒基因。在这里，我们显示NK同源异型盒基因簇是双边动物基因组的古老特征，但在cho酸盐祖先中已被二次分裂。两栖类和脊椎动物的NK同源异型盒基因簇分别分裂并分散在两个相等的基因间位置上。从祖先的NK基因簇，只有Tlx-Lbx和NK3-NK4链接保留在脊索动物中。这种进化模式与Hox和ParaHox基因簇形成鲜明对比，后者在两栖类和脊椎动物中很紧凑，但在果蝇中已被破坏。

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2003年第9期|P.5292-5295|共4页
作者
Luke GN; Castro LF; McLay K; Bird C; Coulson A; Holland PW;
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作者单位

School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading RG6 6AJ, United Kingdom.;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Genes; Homeobox; L; Dispersa; 基因; 同源盒;

机译：Genes;Homeobox;L;Dispersa;基因;同源盒;

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1. AmphiNk2-tin, an amphioxus homeobox gene expressed in myocardial progenitors: insights into evolution of the vertebrate heart [J] . Holland ND., Venkatesh TV., Holland LZ., Developmental biology . 2003,第1期

机译：AmphiNk2-tin，一种在心肌祖细胞中表达的双歧杆菌同源盒基因：对脊椎动物心脏进化的见解
2. Amphink2-tin, an amphioxus homeobox gene expressed in myocardial progenitors: insights into evolution of the vertebrate heart [J] . Nicholas D. Holland, Tyamagondlu V. Venkatesh, Linda Z. Holland, Developmental biology . 2003,第1期

机译：Amphink2-tin，一种在心肌祖细胞中表达的两性同源框基因：洞悉脊椎动物心脏的过程
3. Ancient homeobox gene loss and the evolution of chordate brain and pharynx development: Deductions from amphioxus gene expression [J] . Butts T., Holland P.W.H., Ferrier D.E.K. Proceedings of the Royal Society. Biological sciences . 2010,第1699期

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4. Gene Ontology Based Clustering Analysis for Functionally Linked Genes and Cross-Species Comparison for SSR Biomarkers [C] . Yang-Chun Chang, Chien-Ming Chen, Tun-Wen Pai, International Conference on Complex, Intelligent and Software Intensive Systems . 2016

机译：基于基因本体的功能链接基因聚类分析和SSR生物标记物的种间比较
5. Genetic variation and linkage disequilibrium in the human alcohol dehydrogenase genes: Implications of the evolutionary history of a gene family in humans. [D] . Osier, Michael Vernon. 2002

机译：人类酒精脱氢酶基因的遗传变异和连锁不平衡：人类基因家族进化史的意义。
6. Dispersal of NK homeobox gene clusters in amphioxus and humans [O] . Graham N. Luke, L. Filipe C. Castro, Kirsten McLay, 2003

机译：NK同源盒基因簇在两栖动物和人类中的分散。
7. Dispersal of NK homeobox gene clusters in amphioxus and humans. [O] . Luke, GN, Castro, LF, McLay, K, 2003

机译：在两栖类和人类中NK同源异型盒基因簇的分散。

Dispersal of NK homeobox gene clusters in amphioxus and humans.

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