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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1).
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Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1).

机译：在缺乏趋化因子，基质细胞衍生因子-1（SDF-1）的小鼠中，原始生殖细胞对性腺的定居受损。

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摘要

Primordial germ cells (PGCs) are the founders of sperm or oocytes. PGCs migrate through the tissues of the embryos and colonize the gonads during development. However, the cytokines essential for colonization of the gonads by PGCs in mammals remain unclear. Stromal cell-derived factor-1 (SDF-1, also called PBSF and CXCL12) is a member of chemokines, a family of structurally related chemoattractive cytokines. SDF-1 and its primary physiologic receptor CXCR4 have multiple essential functions in development including colonization of bone marrow by hematopoietic cells and neuron localization within cerebellum during embryogenesis as well as B lymphopoiesis and cardiovasculogenesis. Here, we have shown that PGCs have cell-surface expression of CXCR4 and that, in SDF-1(-/-) mice, PGCs undergo directed migration through tissues of embryos, but the numbers of PGCs in the gonads are significantly reduced. The proliferation of PGCs within the gonads seems normal in the mutant mice. These findings reveal the essential role for SDF-1 in murine PGC development likely by controlling colonization of the gonads by PGCs.
机译：原始生殖细胞（PGC）是精子或卵母细胞的奠基人。 PGC在发育过程中通过胚胎组织迁移并定居性腺。然而，对于哺乳动物中PGCs定性腺定殖所必需的细胞因子仍然不清楚。基质细胞衍生因子1（SDF-1，也称为PBSF和CXCL12）是趋化因子的成员，趋化因子是结构相关的趋化性细胞因子家族。 SDF-1及其主要的生理受体CXCR4在发育中具有多种基本功能，包括在造血以及B淋巴细胞生成和心血管发生过程中造血细胞在骨髓中定植和小脑神经元定位。在这里，我们已经显示PGC具有CXCR4的细胞表面表达，并且在SDF-1（-/-）小鼠中，PGC经历了通过胚胎组织的定向迁移，但是性腺中PGC的数量显着减少。在突变小鼠中，性腺中PGC的增殖似乎是正常的。这些发现揭示了SDF-1在鼠PGC发育中的重要作用，可能是通过控制PGC的性腺定殖来实现的。

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