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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Specificity of peptide selection by antigen-presenting cells homozygous or heterozygous for expression of class II MHC molecules: The lack of competition.
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Specificity of peptide selection by antigen-presenting cells homozygous or heterozygous for expression of class II MHC molecules: The lack of competition.

机译：纯合或杂合的抗原呈递细胞对II类MHC分子表达的肽选择特异性：缺乏竞争。

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摘要

We isolated and identified naturally processed peptides selected by antigen-presenting cells homozygous for expression of I-A(g7) or I-A(d) class II MHC molecules, or from heterozygous antigen-presenting cells that express I-A(g7) along with I-A(g7PD) or I-A(d). Identification of large numbers of peptides demonstrated that despite being closely related on a structural level, each class II MHC molecule selected for very unique peptides. The large data sets allowed us to definitively establish the preferred peptide-binding motifs critical for selection of peptides by I-A(g7), I-A(g7PD), and I-A(d). Finally, extensive analyses of peptide families reveals that there was little competition among class II MHC alleles for display of peptides and that presence of one allele had minimal impact on the repertoire of peptides selected by another.
机译：我们分离并鉴定了天然表达的多肽，这些多肽是由纯合的抗原呈递细胞选择的，用于表达IA（g7）或IA（d）II类MHC分子，或从与IA（g7PD）一起表达IA（g7）的杂合抗原呈递细胞中选择或IA（d）。大量肽的鉴定表明，尽管在结构水平上密切相关，但每个II类MHC分子均选择了非常独特的肽。大数据集使我们能够确定地建立优选的肽结合基序，这些基序对于通过I-A（g7），I-A（g7PD）和I-A（d）选择肽至关重要。最后，对肽家族的广泛分析显示，II类MHC等位基因之间在展示肽方面几乎没有竞争，并且一个等位基因的存在对另一种选择的肽库的影响最小。

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