...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Adeno-associated viruses undergo substantial evolution in primates during natural infections
【24h】

Adeno-associated viruses undergo substantial evolution in primates during natural infections

机译：在自然感染过程中，与腺相关的病毒在灵长类动物中发生大量进化

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Adeno-associated viruses (AAVs) are single-stranded DNA viruses that are endemic in human populations without known clinical sequelae and are being evaluated as vectors for human gene therapy. To better understand the biology of this virus, we examined a number of nonhuman primate species for the presence of previously uncharacterized AAVs and characterized their structure and distribution. AAV genomes were widely disseminated throughout multiple tissues of a variety of nonhuman primate species. Surprising diversity of sequence, primarily localized to hypervariable regions of the capsid protein, was detected. This diversity of sequence is caused, in part, by homologous recombination of co-infecting parental viruses that modify the serologic reactivity and tropism of the virus. This is an example of rapid molecular evolution of a DNA virus in a way that was formerly thought to be restricted to RNA viruses.
机译：腺相关病毒（AAV）是单链DNA病毒，在人类人群中是特有的，没有已知的临床后遗症，正在被评估为人类基因治疗的载体。为了更好地了解这种病毒的生物学特性，我们检查了许多非人类的灵长类动物物种是否存在先前未鉴定的AAV，并对其结构和分布进行了表征。 AAV基因组广泛分布在各种非人类灵长类动物的多个组织中。检测到主要位于衣壳蛋白的高变区的惊人的序列多样性。序列的这种多样性部分是由于共同感染的亲本病毒的同源重组引起的，这些亲本病毒改变了病毒的血清反应性和嗜性。这是DNA病毒快速分子进化的一个例子，这种方式以前被认为仅限于RNA病毒。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号