Antigens in tea-beverage prime human Vγ2Vδ2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses

Arati B. Kamath; Lisheng Wang; Hiranmoy Das; Lin Li; Vernon N. Reinhold; Jack F. Bukowski

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Antigens in tea-beverage prime human Vγ2Vδ2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses

机译：茶饮料中主要的人Vγ2Vδ2T细胞中的抗原在体内和体外对记忆和非记忆性抗菌素的反应

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Human γδ T cells mediate innate immunity to microbes via T cell receptor-dependent recognition of unprocessed antigens with conserved molecular patterns. These nonpeptide alkylamine antigens are shared by tumor cells, bacteria, parasites, and fungi but also by edible plant products such as tea, apples, mushrooms, and wine. Here we show that priming of γδ T cells with alkylamine antigens in vitro results in a memory response to these antigens. Such priming results also in a nonmemory response to whole bacteria and to lipopolysaccharide, characterized by IL-12-depen-tfent secretion of IFN-γ by γδ T cells and by γδ T cell proliferation. Drinking tea, which contains L-theanine, a precursor of the nonpeptide antigen ethylamine, primed peripheral blood γδ T cells to mediate a memory response on reexposure to ethylamine and to secrete IFN-γ in response to bacteria. This unique combination of innate immune response and immunologic memory shows that γδ T cells can function as a bridge between innate and acquired immunity. In addition, these data provide an explanation for the health benefits of tea.

机译：人类γδT细胞通过T细胞受体依赖的未加工抗原的保守分子模式介导对微生物的先天免疫。这些非肽烷基胺抗原被肿瘤细胞，细菌，寄生虫和真菌所共有，但也被可食用植物产品（如茶，苹果，蘑菇和葡萄酒）所共有。在这里，我们显示在体外用烷基胺抗原引发γδT细胞会导致对这些抗原的记忆反应。这种引发还导致了对整个细菌和脂多糖的无记忆反应，其特征在于γδT细胞和γδT细胞增殖的IL-12依赖于IFN-γ的分泌。含有L-茶氨酸（非肽抗原乙胺的前体）的茶可灌注外周血γδT细胞，以介导再暴露于乙胺时的记忆反应，并响应细菌而分泌IFN-γ。先天免疫应答和免疫记忆的这种独特结合表明，γδT细胞可以充当先天免疫与后天免疫之间的桥梁。此外，这些数据为茶的健康益处提供了解释。

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2003年第10期|p.6009-6014|共6页
作者
Arati B. Kamath; Lisheng Wang; Hiranmoy Das; Lin Li; Vernon N. Reinhold; Jack F. Bukowski;
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作者单位

Lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Tumor-Primed, In Vitro-Activated CD4+ Effector T Cells Establish Long-Term Memory without Exogenous Cytokine Support or Ongoing Antigen Exposure [J] . Li-Xin Wang, Gregory E. Plautz The journal of immunology . 2010,第10期

机译：以肿瘤为基础的体外激活的CD4 +效应T细胞在没有外源细胞因子支持或持续进行抗原暴露的情况下建立了长期记忆
2. Tumour antigen-loaded mouse dendritic cells maturing in the presence of inflammatory cytokines are potent activators of immune response in vitro but not in vivo. [J] . Rossowska J, Pajtasz Piasecka E, Szyda A, Oncology reports . 2009,第6期

机译：在炎性细胞因子的存在下成熟的负载肿瘤抗原的小鼠树突状细胞是体外而非体内免疫反应的有效激活剂。
3. Autologous human monocyte-derived dendritic cells genetically modified to express melanoma antigens elicit primary cytotoxic T cell responses in vitro: enhancement by cotransfection of genes encoding the Th1-biasing cytokines IL-12 and IFN-alpha. [J] . Tuting T, Wilson CC, Martin DM, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1998,第3期

机译：经过遗传修饰以表达黑素瘤抗原的自体人类单核细胞衍生的树突状细胞在体外引起主要的细胞毒性T细胞反应：通过共转染编码Th1偏向细胞因子IL-12和IFN-α的基因来增强。
4. Studies of effects on CD antigens expression and cytokines secretion of lymphocytes infected by human herpesvirus 6 and 7 in vitro [C] . Peng Guang-Yong, Yao Kun, Ren Qiang, 7th China-Japan International Congress of Microbiology Shanghai Symposium-2000 4-6 August 2000 Shanghai . 2000

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5. In vitro and in vivo regulation of pro-inflammatory cytokines and drug efflux transporters by signal transduction pathways in glial cells: implications in HIV-1 neuropathogenesis and its treatment. [D] . Ashraf, Tamima. 2015

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6. Antigens in tea-beverage prime human Vγ2Vδ2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses [O] . Arati B. Kamath, Lisheng Wang, Hiranmoy Das, 2003

机译：茶饮料中主要的人Vγ2Vδ2T细胞中的抗原在体内和体外对记忆和非记忆性抗菌素的反应
7. Antigens in tea-beverage prime human Vγ2Vδ2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses [O] . Kamath, Arati B., Wang, Lisheng, Das, Hiranmoy, 2003

机译：茶饮料中主要的人Vγ2Vδ2T细胞中的抗原在体内和体外对记忆和非记忆性抗菌素的反应

Antigens in tea-beverage prime human Vγ2Vδ2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses

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