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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Sexual transmission of the (Het-S) prion leads to meiotic drive in Podospora anserina.
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Sexual transmission of the (Het-S) prion leads to meiotic drive in Podospora anserina.

机译：（Het-S）ion病毒的性传播导致Podospora anserina发生减数分裂驱动。

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In the filamentous fungus Podospora anserina, two phenomena are associated with polymorphism at the het-s locus, vegetative incompatibility and ascospore abortion. Two het-s alleles occur naturally, het-s and het-S. The het-s encoded protein is a prion propagating as a self-perpetuating amyloid aggregate. When prion-infected [Het-s] hyphae fuse with [Het-S] hyphae, the resulting heterokaryotic cells necrotize. [Het-s] and [Het-S] strains are sexually compatible. When, however, a female [Het-s] crosses with [Het-S], a significant percentage of het-S spores abort, in a way similar to spore killing in Neurospora and Podospora. We report here that sexual transmission of the [Het-s] prion after nonisogamous mating in the reproductive cycle of Podospora is responsible for the killing of het-S spores. Progeny of crosses between isogenic strains with distinct wild-type or introduced, ectopic het-s/S alleles were cytologically and genetically analyzed. The effect of het-s/S overexpression, ectopic het-s/S expression, absence of het-s expression, loss of [Het-s] prion infection, and the distribution patterns of HET-s/S-GFP proteins were categorized during meiosis and ascospore formation. This study unveiled a het-S spore-killing system that is governed by dosage of and interaction between the [Het-s] prion and the HET-S protein. Due to this property of the [Het-s] prion, the het-s allele acts as a meiotic drive element favoring maintenance of the prion-forming allele in natural populations.
机译：在丝状真菌Popospora anserina中，两个基因与het-s基因座的多态性有关，即营养不相容和子囊孢子流产。天然存在两个het-s等位基因，het-s和het-S。 het-s编码的蛋白质是a病毒，可作为自持久的淀粉样蛋白聚集体繁殖。当病毒感染的[Het-s]菌丝与[Het-S]菌丝融合时，所得的异核细胞坏死。 [Het-s]和[Het-S]菌株具有性相容性。但是，当雌性[Het-s]与[Het-S]杂交时，大量的het-S孢子会中止，其方式类似于杀死Neurospora和Podospora中的孢子。我们在这里报告说，[Het-s] ion病毒的非性配偶交配后在性繁殖中的性传播是杀死Het-S孢子的原因。对具有不同野生型或引入的异位het-s / S等位基因的同基因菌株之间的杂交后代进行了细胞学和遗传学分析。将het-s / S过表达，异位het-s / S表达，不存在het-s表达，[Het-s] ion病毒感染的丧失以及HET-s / S-GFP蛋白的分布方式的影响进行了分类。在减数分裂和子囊孢子形成过程中。这项研究揭示了一种het-S孢子杀灭系统，该系统由[Het-s] ion病毒和HET-S蛋白的剂量和相互作用决定。由于[Het-s] ion病毒的这一特性，het-s等位基因充当减数分裂驱动元件，有利于在自然种群中维持形成pr病毒的等位基因。

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