...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Positional cloning of the young mutation identifies an essential role for the Brahma chromatin remodeling complex in mediating retinal cell differentiation
【24h】

Positional cloning of the young mutation identifies an essential role for the Brahma chromatin remodeling complex in mediating retinal cell differentiation

机译：年轻突变的位置克隆确定了婆罗门染色质重塑复合体在介导视网膜细胞分化中的重要作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Zebrafish with the young (yng) mutation show a defect in retinal cell differentiation. Here we demonstrate that a mutation in a brahma-related gene (brg1) is responsible for the yng phenotype. Brahma homologues function as essential subunits for SWI/SNF-type chromatin remodeling complexes. Our analysis indicates that brg1 is required for the wave of mitogen-activated protein kinase activity that precedes retinal cell differentiation. Using specific inhibitors of the mitogen-activated protein kinase pathway we show this signal has a direct role in retinal cell differentiation. Lastly, through investigations of mutants in other chromatin remodeling subunits, we provide genetic evidence for gene and tissue specificity of the Brahma chromatin remodeling complex. [References: 41]
机译：具有年轻（yng）突变的斑马鱼显示视网膜细胞分化缺陷。在这里，我们证明婆罗门相关基因（brg1）中的突变负责yng表型。梵天同源物作为SWI / SNF型染色质重塑复合物的必需亚基。我们的分析表明，在视网膜细胞分化之前，有丝分裂原激活的蛋白激酶活性需要brg1。使用有丝分裂原激活的蛋白激酶途径的特异性抑制剂，我们显示该信号在视网膜细胞分化中具有直接作用。最后，通过调查其他染色质重塑亚基中的突变体，我们为梵天染色质重塑复合体的基因和组织特异性提供了遗传证据。 [参考：41]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号