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A fratricidal fungal prion

机译:杀真菌真菌病毒

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摘要

Once again, 50 years after its discovery, the multifaceted het-s gene of Podospora anse-rina has surprised us. Long ago, it provided an important early example of heterokaryon incompatibility and cytoplasmic inheritance. In 1997, the product of allele het-s was shown to form a prion (infectious protein) that leads to cell death in incompatible combinations. Then, spore-killing meiotic drive factors were discovered in natural populations of Podospom. Ability to kill was correlated with heterokaryon incompatibility, and some of the killer strains resembled het-s in their effects on asco-spore abortion. Now, in this issue of PNAS, Dalstra et al. (10) fit pieces of the jigsaw puzzle together, showing that the het-s prion acts as a spore killer in the sexual phase. It can thus be thought of as a selfish genetic element that promotes its maintenance by actively destroying meiotic products that bear the nonprion allele het-S.
机译:在被发现后的50年中,波多孢菌anse-rina的多方面het-s基因再次使我们感到惊讶。很久以前,它为异核体不相容和细胞质遗传提供了重要的早期实例。 1997年,等位基因het-s的产物显示形成form病毒(感染性蛋白质),导致不相容的组合导致细胞死亡。然后,在Podospom的自然种群中发现了杀死孢子的减数分裂驱动因子。杀伤能力与异核体的不相容性相关,某些杀伤菌株对孢子流产的影响类似于het-s。现在,在本期PNAS中,Dalstra等人。 (10)将拼图玩具拼合在一起,表明在性阶段,het-s pr病毒可作为杀孢子。因此,可以认为它是一种自私的遗传元件,可通过主动破坏带有非ion病毒等位基因het-S的减数分裂产物来促进其维持。

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