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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Mapping the genetic variation of executive attention onto brain activity
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Mapping the genetic variation of executive attention onto brain activity

机译：将行政注意的遗传变异映射到大脑活动

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Brain imaging data have repeatedly shown that the anterior cingulate cortex is an important node in the brain network mediating conflict. We previously reported that polymorphisms in dopamine receptor (DRD4) and monoamine oxidase A (MAOA) genes showed significant associations with efficiency of handling conflict as measured by reaction time differences in the Attention Network Test (ANT). To examine whether this genetic variation might contribute to differences in brain activation within the anterior cingulate cortex, we genotyped 16 subjects for the DRD4 and MAOA genes who had been scanned during the ANT. In each of the two genes previously associated with more efficient handling of conflict in reaction time experiments, we found a polymorphism in which persons with the allele associated with better behavioral performance showed significantly more activation in the anterior cingulate while performing the ANT than those with the allele associated with worse performance. The results demonstrate how genetic differences among individuals can be linked to individual differences in neuromodulators and in the efficiency of the operation of an appropriate attentional network. [References: 29]
机译：脑成像数据反复表明，前扣带回皮层是介导冲突的脑网络中的重要节点。我们先前曾报道多巴胺受体（DRD4）和单胺氧化酶A（MAOA）基因的多态性显示出与处理冲突效率的显着关联，如通过注意力网络测试（ANT）中的反应时间差异所衡量。为了检查这种遗传变异是否可能导致前扣带回皮层内大脑激活的差异，我们对ANT期间扫描的DRD4和MAOA基因进行了16位受试者的基因分型。在先前与反应时间实验中冲突的更有效处理相关的两个基因的每一个中，我们发现了一种多态性，其中等位基因与更好的行为表现相关的人在执行ANT时比前者具有显着更多的前扣带回激活。等位基因与较差的表现有关。结果表明，个体之间的遗传差异如何与神经调节剂的个体差异以及适当的注意网络的运作效率相关联。 [参考：29]

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