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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Bacterial cell division spirals into control
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Bacterial cell division spirals into control

机译：细菌细胞分裂成螺旋状

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Directing proteins to specific sub-cellular addresses is a central problem in cell biology. Historically, perhaps because of their general lack of compartmentalized or-ganelles, bacteria were viewed as relatively uniform at the subcellular level. However, with advances in fluorescence microscopy came the realization that bacteria, like their eukaryotic counterparts, segregate their proteins to different cellular regions . Recent studies have extended this principle by demonstrating that bacteria not only localize intracellular proteins to distinct regions of the cell, but that within these regions they can also organize proteins into discrete ordered structures. For example, the actin homologs MreB and Mbl form spirals along the long axis of Bacillus subtilis, and the cytokinetic tubulin homolog FtsZ localizes to a ring that goes through a spiral intermediate to reposition itself during B. subtilis sporula-tion. The work of Shih et al. in this issue of PNAS demonstrates that the ability of intracellular proteins to organize into ordered structures is not exclusive to bacterial cytoskeletal elements. The authors make the exciting observation that proteins that were once thought to diffusely oscillate between the cell poles are in fact present in ordered spirals.
机译：将蛋白质定向到特定的亚细胞地址是细胞生物学中的中心问题。从历史上看，也许是由于它们普遍缺乏间隔的或小节，细菌在亚细胞水平上被认为是相对均匀的。然而，随着荧光显微镜技术的发展，人们意识到细菌像真核生物一样，将其蛋白质分离到不同的细胞区域。最近的研究通过证明细菌不仅将胞内蛋白定位于细胞的不同区域，而且还可以在这些区域内将蛋白质组织成离散的有序结构，从而扩展了这一原理。例如，肌动蛋白同源物MreB和Mbl沿着枯草芽孢杆菌的长轴形成螺旋形，而细胞动力学微管蛋白同源物FtsZ定位于一个环，该环通过螺旋中间物在枯草芽孢杆菌形成孢子期间重新定位。 Shih等人的工作。本期《 PNAS》证明，细胞内蛋白质组织成有序结构的能力并非细菌细胞骨架成分所独有。这组作者做出了令人振奋的观察，即曾经被认为在细胞极之间扩散振荡的蛋白质实际上存在于有序螺旋中。

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