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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >CD40 ligand is a critical effector of Epstein-Barr virus in host cell survival and transformation
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CD40 ligand is a critical effector of Epstein-Barr virus in host cell survival and transformation

机译：CD40配体是爱泼斯坦巴尔病毒在宿主细胞存活和转化中的关键作用

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摘要

Epstein-Barr virus (EBV), implicated in numerous human diseases, including lymphoid malignancies, persistently infects peripheral B cells and transforms them into lymphoblastoid cell lines. Here we found that EBV equally infected B cells from patients with X-linked hyper IgM syndrome and those from healthy donors; however, it hardly transformed X-linked hyper IgM syndrome B cells, because of the dysfunctional gene of CD40 ligand (CD40L) of the patients. Unlike CD40, CD40L is not usually expressed on B cells. However, we found that EBV infection of normal B cells induced CD40L expression as a critical effector in host cell transformation and survival. Moreover, chronic active EBV infection of peripheral T cells, implicated in T cell malignancies, was associated with ectopic expression of CD40, and, in Jurkat T cells, EBV infection induced CD40 expression. These results suggest that EBV infection induces CD40L/CD40 signaling in host cells, which appears to play an essential role in its persistent infection and malignancies of lymphocytes. [References: 30]
机译：爱泼斯坦-巴尔病毒（EBV）与许多人类疾病有关，包括淋巴样恶性肿瘤，持续感染周围的B细胞并将其转化为淋巴母细胞样细胞系。在这里，我们发现EBV感染了X连锁性高IgM综合征患者和健康供体的B细胞。然而，由于患者的CD40配体（CD40L）的基因功能异常，它几乎不能转化X连锁的高IgM综合征B细胞。与CD40不同，CD40L通常不在B细胞上表达。但是，我们发现正常B细胞​​的EBV感染诱导CD40L表达，这是宿主细胞转化和存活中的关键效应子。此外，与T细胞恶性肿瘤有关的外周T细胞的慢性主动EBV感染与CD40的异位表达有关，在Jurkat T细胞中，EBV感染诱导CD40的表达。这些结果表明，EBV感染在宿主细胞中诱导CD40L / CD40信号传导，这似乎在其持续感染和淋巴细胞恶性肿瘤中起重要作用。 [参考：30]

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