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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro.
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In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro.

机译：从体外行为无法预测的抗原特异性调节性T细胞的体内动力学。

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摘要

Adoptive transfer of antigen-specific CD25+CD4+ regulatory T cells was used to analyze the stability of their phenotype, their behavior after immunization, and their mode of suppressing cotransferred naive T cells in vivo. We found that regulatory T cells maintained their phenotype in the absence of antigen, were not anergic in vivo, and proliferated as extensively as naive CD4+ T cells after immunization without losing their suppressive function in vivo and in vitro. In vivo, the expansion of cotransferred naive T cells was suppressed relatively late in the response such that regulatory T cells expressing mostly IL-10 but not IL-2 or IFN-gamma represented the dominant subset of cells. Our results reveal properties of regulatory T cells that were not predicted from in vitro studies.
机译：使用抗原特异性CD25 + CD4 +调节性T细胞的过继转移来分析其表型的稳定性，免疫后的行为以及在体内抑制共转移的天然T细胞的方式。我们发现，调节性T细胞在没有抗原的情况下仍保持其表型，在体内不是无反应的，并且在免疫后在不失去其体内和体外抑制功能的情况下，像幼稚的CD4 + T细胞一样广泛增殖。在体内，共转移的天然T细胞的扩增在反应中相对较晚地被抑制，使得主要表达IL-10但不表达IL-2或IFN-γ的调节性T细胞代表了细胞的主要子集。我们的结果揭示了体外研究未预测到的调节性T细胞的特性。

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